Invention Grant
- Patent Title: Process for the manufacture of epoxybutanol intermediates
- Patent Title (中): 制备环氧丁醇中间体的方法
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Application No.: US12085617Application Date: 2006-11-29
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Publication No.: US07816537B2Publication Date: 2010-10-19
- Inventor: Marc Muller , Lin Xu
- Applicant: Marc Muller , Lin Xu
- Applicant Address: CH Basel
- Assignee: Basilea Pharmaceutica AG
- Current Assignee: Basilea Pharmaceutica AG
- Current Assignee Address: CH Basel
- Priority: EP05026163 20051201
- International Application: PCT/CH2006/000671 WO 20061129
- International Announcement: WO2007/062542 WO 20070607
- Main IPC: C07D301/32
- IPC: C07D301/32 ; C07D303/14 ; C07D249/08 ; C07D277/24

Abstract:
Disclosed is a process for the manufacture of a compound of formula (I) wherein Hal represents fluoro or chloro, and R1 and R2 represent, independently from one another, hydrogen or Hal; in which process a compound of formula (II) is converted to a corresponding alkyl, fluoroalkyl or aryl sulfonic acid ester, which is then reacted with an alkali metal nitrite in the presence of a suitable crown ether in a polar non-nucleophilic solvent at a temperature of −10 to 50° C. to give the compound of formula (I).
Public/Granted literature
- US20090299073A1 Process for the Manufacture of Epoxybutanol Intermediates Public/Granted day:2009-12-03
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