发明授权
US07829063B2 Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry
有权
使用点击化学开发碳酸酐酶IX的分子成像探针
- 专利标题： Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry
- 专利标题（中）： 使用点击化学开发碳酸酐酶IX的分子成像探针
-
申请号： US12099135申请日： 2008-04-07
-
公开(公告)号： US07829063B2公开(公告)日： 2010-11-09
- 发明人: Hartmuth C. Kolb , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Bing Wang , Umesh B. Gangadharmath , Brian A. Duclos , Kai Chen , Wei Zhang , Gang Chen , Henry Clifton Padgett , Farhad Karimi , Peter J. H. Scott , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Tieming Zhao , Chunfang Xia
- 申请人： Hartmuth C. Kolb , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Bing Wang , Umesh B. Gangadharmath , Brian A. Duclos , Kai Chen , Wei Zhang , Gang Chen , Henry Clifton Padgett , Farhad Karimi , Peter J. H. Scott , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Tieming Zhao , Chunfang Xia
- 申请人地址： US PA Malvern
- 专利权人： Siemens Medical Solutions USA, Inc.
- 当前专利权人： Siemens Medical Solutions USA, Inc.
- 当前专利权人地址： US PA Malvern
- 代理商 Joshua Ryan
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; C07D343/00
摘要：
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.