发明授权
- 专利标题： Compounds and methods for diagnosis and treatment of leishmaniasis
- 专利标题（中）： 利什曼病诊断和治疗的化合物和方法
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申请号： US11733440申请日： 2007-04-10
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公开(公告)号： US07833534B2公开(公告)日： 2010-11-16
- 发明人: Yasuyuki Goto , Steven G. Reed
- 申请人： Yasuyuki Goto , Steven G. Reed
- 申请人地址： US WA Seattle
- 专利权人： Infectious Disease Research Institute
- 当前专利权人： Infectious Disease Research Institute
- 当前专利权人地址： US WA Seattle
- 代理机构： Graybeal Jackson LLP
- 代理商 Dylan O. Adams
- 主分类号： A61K39/02
- IPC分类号： A61K39/02 ; A61K49/00 ; A61N63/00
摘要：
Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.
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