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    Broad-spectrum tumor suppressor genes gene products and methods for tumor suppressor gene therapy
    1.
    发明授权
    Broad-spectrum tumor suppressor genes gene products and methods for tumor suppressor gene therapy 失效
    广谱肿瘤抑制基因基因产物及肿瘤抑制基因治疗方法

    公开(公告)号：US5912236A

    公开(公告)日：1999-06-15

    申请号：US470091

    申请日：1995-06-06

    申请人： Hong-Ji Xu ,  Shi-Xue Hu ,  William F. Benedict

    发明人： Hong-Ji Xu ,  Shi-Xue Hu ,  William F. Benedict

    IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C07H21/04 ,  C07K14/47 ,  C12N5/10 ,  C12P21/02 ,  A01N43/04 ,  A61N63/00

    CPC分类号： A61K31/70 ,  C07K14/4736 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate host cells. The protein is a second in-frame AUG codon-initiated retinoblasoma protein of about 94 kD relative molecular mass. The present invention also relates to methods of treating a mammal having a disease or disorder characterized by abnormal cellular proliferation, such as a tumor or cancer and methods of treating abnormally proliferating cells, such as tumor or cancer cells. Treatment is accomplished by inserting a host cell compatible p94.sup.RB expression vector or an effective amount of p94.sup.RB protein into a cell or cells in need of treatment.

    摘要翻译： 本发明涉及广谱肿瘤抑制基因和由该基因在合适的宿主细胞中表达的蛋白质。 该蛋白质是第二个具有约94kD相对分子量的框内AUG密码子起始的视网膜母细胞瘤蛋白。 本发明还涉及治疗以异常细胞增殖为特征的疾病或病症如肿瘤或癌症的哺乳动物的治疗方法以及治疗异常增殖细胞如肿瘤或癌细胞的方法。 通过将宿主细胞相容的p94RB表达载体或有效量的p94RB蛋白插入到需要治疗的细胞或细胞中来完成治疗。

    Compounds and methods for diagnosis and treatment of leishmaniasis
    2.
    发明授权
    Compounds and methods for diagnosis and treatment of leishmaniasis 有权
    利什曼病诊断和治疗的化合物和方法

    公开(公告)号：US07833534B2

    公开(公告)日：2010-11-16

    申请号：US11733440

    申请日：2007-04-10

    申请人： Yasuyuki Goto ,  Steven G. Reed

    发明人： Yasuyuki Goto ,  Steven G. Reed

    IPC分类号： A61K39/02 ,  A61K49/00 ,  A61N63/00

    CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

    摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

    摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。

    Methods and compounds for the targeting of protein to exosomes
    4.
    发明授权
    Methods and compounds for the targeting of protein to exosomes 有权
    用于将蛋白质靶向外来体的方法和化合物

    公开(公告)号：US07704964B2

    公开(公告)日：2010-04-27

    申请号：US10485360

    申请日：2002-08-14

    申请人： Alain Delcayre ,  Jean-Bernard Le Pecq

    发明人： Alain Delcayre ,  Jean-Bernard Le Pecq

    IPC分类号： A61K31/70 ,  C12N15/74 ,  C12N15/09 ,  A61N63/00

    CPC分类号： C12N15/62 ,  A61K47/64 ,  A61K47/6901 ,  C07K14/47 ,  C07K14/55 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/41 ,  C07K2319/75

    摘要： The present invention relates to compositions and methods for selectively expressing a polypeptide in a membrane vesicle. The invention also relates to genetic constructs and recombinant cells suitable to produce such membrane vesicles. This invention also relates to such functionalized membrane vesicles as well as to methods of making antibodies, methods of producing or regulating an immune response as well as to methods of screening or identifying binding partners using the same. The invention more particularly uses lactadherin or portions thereof to selectively express polypeptides in membrane vesicles, of natural or synthetic origin. This invention can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.

    摘要翻译： 本发明涉及用于在膜囊泡中选择性表达多肽的组合物和方法。 本发明还涉及适于产生这种膜囊泡的遗传构建体和重组细胞。 本发明还涉及这种功能化膜囊泡以及制备抗体的方法，产生或调节免疫应答的方法以及筛选或鉴定使用其的结合配偶体的方法。 本发明更特别地使用乳胶素或其部分选择性地表达天然或合成来源的膜囊泡中的多肽。 本发明可用于实验，研究，治疗，预防或诊断领域。

    Strain of micro-organism Lactobacillus fermentum ME-3 as novel anti-microbiol and anti-oxidative probiotic
    5.
    发明授权
    Strain of micro-organism Lactobacillus fermentum ME-3 as novel anti-microbiol and anti-oxidative probiotic 有权
    微生物菌株发酵乳杆菌ME-3作为新型抗微生物和抗氧化益生菌

    公开(公告)号：US07244424B2

    公开(公告)日：2007-07-17

    申请号：US10481713

    申请日：2002-06-21

    申请人： Marika Mikelsaar ,  Mihkel Zilmer ,  Tiiu Kullisaaar ,  Heidi Annuk ,  Epp Songisepp

    发明人： Marika Mikelsaar ,  Mihkel Zilmer ,  Tiiu Kullisaaar ,  Heidi Annuk ,  Epp Songisepp

    IPC分类号： A61N63/00

    CPC分类号： A61K35/747 ,  Y02A50/473 ,  Y02A50/475

    摘要： The strain of micro-organism Lactobacillus fermentum ME-3 is a novel anti-microbial and anti-oxidative probiotic. It has a high anti-microbial effect on Escherichia coli, Shigella sonnei, Staphylococcus aureus, Salmonella typhimurium, and moderate activity against Helicobacter pylori strains. The strain of micro-organism possesses Mn-superoxide dismutase and both its lysates and intact cells have high anti-oxidative activity, increasing the glutathione red-ox ratio in blood sera and able to capture toxic hydroxyl radicals. The strain of micro-organism could be used as a probiotic for the production of functional food (yoghurt, cheese) and non-comestibles (tablets, capsules) for the prophylaxis of intestinal and uroinfections, both for the prevention and treatment of chronic diseases, caused by prolonged oxidative stress.

    摘要翻译： 微生物发酵乳杆菌ME-3的菌株是一种新型的抗微生物和抗氧化益生菌。 对大肠杆菌，志贺氏菌，金黄色葡萄球菌，鼠伤寒沙门氏菌和对幽门螺杆菌菌株的中度活性具有高抗微生物作用。 微生物菌株具有Mn超氧化物歧化酶，其裂解物和完整细胞均具有高抗氧化活性，增加血清中的谷胱甘肽红 - 氧比，能够捕获有毒的羟基自由基。 微生物菌株可用作生产用于预防和治疗慢性疾病的肠道和尿道感染的功能性食物（酸奶，奶酪）和非食品（片剂，胶囊）的益生菌， 由长时间的氧化应激引起。