发明授权
US07838239B2 Methods regarding enhanced T-cell receptor-mediated tumor necrosis factor superfamily mRNA expression in peripheral blood leukocytes in patients with crohn's disease
有权
关于克罗恩病患者外周血白细胞增强的T细胞受体介导的肿瘤坏死因子超家族mRNA表达的方法
- 专利标题： Methods regarding enhanced T-cell receptor-mediated tumor necrosis factor superfamily mRNA expression in peripheral blood leukocytes in patients with crohn's disease
- 专利标题（中）： 关于克罗恩病患者外周血白细胞增强的T细胞受体介导的肿瘤坏死因子超家族mRNA表达的方法
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申请号： US12296425申请日： 2007-04-05
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公开(公告)号： US07838239B2公开(公告)日： 2010-11-23
- 发明人: Masato Mitsuhashi , Stephan R. Targan
- 申请人： Masato Mitsuhashi , Stephan R. Targan
- 申请人地址： JP Tokyo US CA Irvine US CA Los Angeles
- 专利权人： Hitachi Chemical Co., Ltd.,Hitachi Chemical Research Center, Inc.,Cedars-Sinai Medical Center
- 当前专利权人： Hitachi Chemical Co., Ltd.,Hitachi Chemical Research Center, Inc.,Cedars-Sinai Medical Center
- 当前专利权人地址： JP Tokyo US CA Irvine US CA Los Angeles
- 代理机构： Knobbe Martens Olson & Bear LLP
- 国际申请： PCT/US2007/008597 WO 20070405
- 国际公布： WO2007/117611 WO 20071018
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohn's disease is disclosed. A method of monitoring the disease state over time in Crohn's disease patients is also disclosed.
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