发明授权
US07838247B2 Antibody specific for mutant presenilin 2 and method of use thereof
有权
突变型早老素2特异性抗体及其使用方法
- 专利标题： Antibody specific for mutant presenilin 2 and method of use thereof
- 专利标题（中）： 突变型早老素2特异性抗体及其使用方法
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申请号： US11894723申请日： 2007-08-20
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公开(公告)号： US07838247B2公开(公告)日： 2010-11-23
- 发明人: Peter H. St. George-Hyslop , Johanna M. Rommens , Paul E. Fraser
- 申请人： Peter H. St. George-Hyslop , Johanna M. Rommens , Paul E. Fraser
- 申请人地址： CA Toronto, Ontario CA Toronto, Ontario
- 专利权人： HSC Research and Development Limited Partnership,The Governing Council of the University of Toronto
- 当前专利权人： HSC Research and Development Limited Partnership,The Governing Council of the University of Toronto
- 当前专利权人地址： CA Toronto, Ontario CA Toronto, Ontario
- 代理机构： Ropes & Gray LLP
- 代理商 James F. Haley, Jr.; Raymond M. Doss
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K16/18 ; C12P21/08 ; C12N5/20
摘要：
The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes.
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