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公开(公告)号：US6117978A
公开(公告)日：2000-09-12
申请号：US124698
申请日：1998-07-29
IPC分类号： A01K67/027 , A01K67/033 , A61K31/70 , A61K38/00 , A61K38/18 , A61K48/00 , A61P25/28 , C07K14/47 , C07K16/44 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12Q1/68 , C07K14/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , C07K14/4711 , C07K16/28 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C12N2799/021 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了两种人早衰幼苗基因PS-1和PS-2的识别，分离和克隆，其导致家族性阿尔茨海默氏病。 还鉴定了小鼠，秀丽隐杆线虫和黑腹果蝇中的早老素同源基因。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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公开(公告)号：US5840540A
公开(公告)日：1998-11-24
申请号：US967101
申请日：1997-11-10
IPC分类号： A01K67/027 , A01K67/033 , A61K31/70 , A61K38/00 , A61K38/18 , A61K48/00 , A61P25/28 , C07K14/47 , C07K16/44 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12Q1/68 , C12P21/06 , C07H17/00 , C07K14/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , C07K14/4711 , C07K16/28 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C12N2799/021 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了两种人早衰幼苗基因PS-1和PS-2的识别，分离和克隆，其导致家族性阿尔茨海默氏病。 还鉴定了小鼠，秀丽隐杆线虫和黑腹果蝇中的早老素同源基因。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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公开(公告)号：US06531586B1
公开(公告)日：2003-03-11
申请号：US08431048
申请日：1995-04-28
IPC分类号： C12N1511
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0312 , A61K38/00 , C07K14/4711
摘要： The present invention relates to the identification, isolation and cloning of a mammalian polynucleotide which encodes a Alzheimer's related membrane protein (ARMP). The invention also contemplates mutant polynucleotides and polynucleotides that encode ARMP homologs. Vectors encoding the protein and host cells transfected with the vector are further contemplated by the present invention.
摘要翻译： 本发明涉及编码阿尔茨海默氏病相关膜蛋白（ARMP）的哺乳动物多核苷酸的鉴定，分离和克隆。 本发明还考虑了编码ARMP同系物的突变体多核苷酸和多核苷酸。 编码用载体转染的蛋白质和宿主细胞的载体进一步由本发明考虑。
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公开(公告)号：US06395960B1
公开(公告)日：2002-05-28
申请号：US09124523
申请日：1998-07-29
IPC分类号： A01K6700
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C07K14/4711 , C07K16/28 , C12N2799/021 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了两种人早衰幼苗基因PS-1和PS-2的识别，分离和克隆，其导致家族性阿尔茨海默氏病。 还鉴定了小鼠，秀丽隐杆线虫和黑腹果蝇中的早老素同源基因。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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公开(公告)号：US07838247B2
公开(公告)日：2010-11-23
申请号：US11894723
申请日：2007-08-20
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C07K14/4711 , C07K16/28 , C12N2799/021 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了染色体14上的阿尔茨海默氏相关膜蛋白（ARMP）基因和染色体1上的相关基因E5-1的鉴定，分离，克隆和测定。两种基因的正常和突变拷贝都呈现。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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6.发明授权Methods for determining risk of developing alzheimer's disease by detecting mutations in the presenilin 2 (PS-2) gene 有权通过检测早老素2（PS-2）基因突变来确定发生阿尔茨海默病风险的方法公开(公告)号：US06485911B1
公开(公告)日：2002-11-26
申请号：US09636796
申请日：2000-08-11
IPC分类号： C12Q168
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C07K14/4711 , C07K16/28 , C12N2799/021 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了两种人早衰幼苗基因PS-1和PS-2的识别，分离和克隆，其导致家族性阿尔茨海默氏病。 还鉴定了小鼠，秀丽隐杆线虫和黑腹果蝇中的早老素同源基因。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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公开(公告)号：US5986054A
公开(公告)日：1999-11-16
申请号：US592541
申请日：1996-01-26
IPC分类号： A01K67/027 , A01K67/033 , A61K31/70 , A61K38/00 , A61K38/18 , A61K48/00 , A61P25/28 , C07K14/47 , C07K16/44 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12Q1/68 , C07K14/00 , C12P21/06
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , C07K14/4711 , C07K16/28 , G01N33/6896 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C12N2799/021 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了两种人早衰幼苗基因PS-1和PS-2的识别，分离和克隆，其导致家族性阿尔茨海默氏病。 还鉴定了小鼠，秀丽隐杆线虫和黑腹果蝇中的早老素同源基因。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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8.发明授权公开(公告)号：US07846679B2
公开(公告)日：2010-12-07
申请号：US12259668
申请日：2008-10-28
IPC分类号： G01N33/53
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C07K14/4711 , C07K16/28 , C12N2799/021 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了染色体14上的阿尔茨海默氏相关膜蛋白（ARMP）基因和染色体1上的相关基因E5-1的鉴定，分离，克隆和测定。两种基因的正常和突变拷贝都呈现。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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9.发明申请公开(公告)号：US20090191650A1
公开(公告)日：2009-07-30
申请号：US12259668
申请日：2008-10-28
IPC分类号： G01N33/536
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C07K14/4711 , C07K16/28 , C12N2799/021 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了染色体14上的阿尔茨海默氏相关膜蛋白（ARMP）基因和染色体1上的相关基因E5-1的鉴定，分离，克隆和测定。两种基因的正常和突变拷贝都呈现。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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公开(公告)号：US07507798B2
公开(公告)日：2009-03-24
申请号：US11070405
申请日：2005-02-24
IPC分类号： C07K16/28
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C07K14/4711 , C07K16/28 , C12N2799/021 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes.
摘要翻译： 本发明描述了染色体14上的阿尔茨海默氏相关膜蛋白（ARMP）基因和染色体1上的相关基因E5-1的鉴定，分离，克隆和测定。两种基因的正常和突变拷贝都呈现。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。
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