发明授权
US07842719B2 Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
失效
使用内过氧化物治疗由黄病毒引起的感染，包括丙型肝炎，牛病毒性腹泻和古典猪瘟病毒
- 专利标题： Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
- 专利标题（中）： 使用内过氧化物治疗由黄病毒引起的感染，包括丙型肝炎，牛病毒性腹泻和古典猪瘟病毒
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申请号： US10664008申请日： 2003-09-16
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公开(公告)号： US07842719B2公开(公告)日： 2010-11-30
- 发明人: Benedikt Sas , Johan Van hemel , Jan Vandenkerckhove , Eric Peys , Johan Neyts
- 申请人： Benedikt Sas , Johan Van hemel , Jan Vandenkerckhove , Eric Peys , Johan Neyts
- 申请人地址： US IA Des Moines
- 专利权人： Kemin Foods, L.C.
- 当前专利权人： Kemin Foods, L.C.
- 当前专利权人地址： US IA Des Moines
- 代理商 Kent A. Herink; Emily E. Harris
- 主分类号： A61K31/335
- IPC分类号： A61K31/335 ; A61K38/00
摘要：
The use of sesquiterpenes and, in particular sesquiterpene lactone endoperoxides, such as artemisinin and analogs thereof, for the treatment of hepatitis C virus infections. Artemisinin, analogs of artemsisnin and some crude Artemisia extracts were tested in vitro against DNA-viruses, retro-viruses and Flavivirida, (an important family of human and animal RNA pathogens). These compounds were also screened for anti-tumor activity. Strong activity of artemisinin was noticed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), we can conclude that endoperoxides in general and artemisinin more specifically have efficacy as treatments for hepatitis C viral infections.
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