A virtual mouse driving apparatus and method for processing a variety of gesture commands as equivalent mouse commands based on two-handed gesture information obtained by a video camera are provided. The virtual mouse driving method includes: keeping track of an input gesture input with the video camera; removing a background portion of the input gesture image and extracting a left-hand region and a right-hand region from the input gesture image whose background portion has been removed; recognizing a left-hand gesture and a right-hand gesture from the extracted left-hand region and the extracted right-hand region, respectively, and recognizing gesture commands corresponding to the recognition results; and executing the recognized gesture commands.