发明授权
- 专利标题： Indolinone derivatives substituted in the 6 position, their preparation and their use as medicaments
- 专利标题（中）： 6位置取代的吲哚啉酮衍生物及其作为药物的用途
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申请号： US12421820申请日： 2009-04-10
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公开(公告)号： US07858616B2公开(公告)日： 2010-12-28
- 发明人: Gerald Juergen Roth , Armin Heckel , Thorsten Lehmann-Lintz , Joerg Kley , Frank Hilberg , Jacobus C. A. Van Meel , Ulrike Tontsch-Grunt
- 申请人： Gerald Juergen Roth , Armin Heckel , Thorsten Lehmann-Lintz , Joerg Kley , Frank Hilberg , Jacobus C. A. Van Meel , Ulrike Tontsch-Grunt
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人： Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址： DE Ingelheim am Rhein
- 代理商 Michael P. Morris; Edouard G. Lebel
- 优先权： DE10233366 20020723; DE10328533 20030624
- 主分类号： A61K31/541
- IPC分类号： A61K31/541 ; A61K31/404 ; A61K31/496 ; A61P35/00
摘要：
The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in Claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
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