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发明授权
US07863434B2 Characterization of granulocytic Ehrlichia and methods of use 有权
粒细胞Ehrlichia的表征和使用方法

Characterization of granulocytic Ehrlichia and methods of use
摘要：
The present invention relates, in general, to granulocytic ehrlichia (GE) proteins. In particular, the present invention relates to nucleic acid molecules coding for GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; purified GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; a method of detecting nucleic acids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with ehrlichiosis; therapeutic uses, specifically vaccines comprising S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides or nucleic acids; and methods of preventing or inhibiting ehrlichiosis in an animal.
摘要（中）：

本发明一般涉及粒细胞性埃里希（GE）蛋白质。 特别地，本发明涉及编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质的核酸分子; 纯化的GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质和多肽; 重组核酸分子; 含有重组核酸分子的细胞; 具有GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质和多肽特异性结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质的核酸的核酸探针; 检测样品中编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白或多肽的核酸的方法; 含有核酸探针或抗体的试剂盒; 使用本发明的核酸序列，蛋白质或抗体的生物测定来诊断，评估或预测患有埃里希氏菌病的哺乳动物; 特别是包含S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白或多肽或核酸的疫苗; 以及预防或抑制动物中的禽病毒的方法。

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