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    Characterization of granulocytic ehrlichia and methods of use
    2.
    发明授权
    Characterization of granulocytic ehrlichia and methods of use 有权
    粒细胞的表达及其使用方法

    公开(公告)号：US08093008B2

    公开(公告)日：2012-01-10

    申请号：US12859236

    申请日：2010-08-18

    申请人： Cheryl Murphy ,  James Storey ,  Gerald A. Beltz ,  Richard T. Coughlin

    发明人： Cheryl Murphy ,  James Storey ,  Gerald A. Beltz ,  Richard T. Coughlin

    IPC分类号： G01N33/53 ,  A61K39/02 ,  A61K39/00

    CPC分类号： C07K14/29 ,  A01K2217/05 ,  A61K39/00 ,  A61K2039/51 ,  Y02A50/403

    摘要： The present invention relates, in general, to granulocytic ehrlichia (GE) proteins. In particular, the present invention relates to nucleic acid molecules coding for GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; purified GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; a method of detecting nucleic acids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with ehrlichiosis; therapeutic uses, specifically vaccines comprising S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides or nucleic acids; and methods of preventing or inhibiting ehrlichiosis in an animal.

    摘要翻译： 本发明一般涉及粒细胞性埃里希（GE）蛋白质。 特别地，本发明涉及编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质的核酸分子; 纯化的GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质和多肽; 重组核酸分子; 含有重组核酸分子的细胞; 具有GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质和多肽特异性结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质的核酸的核酸探针; 检测样品中编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质或多肽的核酸的方法; 含有核酸探针或抗体的试剂盒; 使用本发明的核酸序列，蛋白质或抗体的生物测定来诊断，评估或预测患有埃里希氏菌病的哺乳动物; 特别是包含S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白或多肽或核酸的疫苗; 以及预防或抑制动物中的禽病毒的方法。

    Characterization of Granulocytic Ehrlichia and Methods of Use
    3.
    发明申请
    Characterization of Granulocytic Ehrlichia and Methods of Use 有权
    粒细胞埃立克氏杆菌的表征和使用方法

    公开(公告)号：US20110045605A1

    公开(公告)日：2011-02-24

    申请号：US12859236

    申请日：2010-08-18

    申请人： Cheryl Murphy ,  James Storey ,  Geraid A. Beltz ,  Richard T. Coughlin

    发明人： Cheryl Murphy ,  James Storey ,  Geraid A. Beltz ,  Richard T. Coughlin

    IPC分类号： G01N33/566 ,  C07K14/00 ,  C07K7/06 ,  C07K7/08

    CPC分类号： C07K14/29 ,  A01K2217/05 ,  A61K39/00 ,  A61K2039/51 ,  Y02A50/403

    摘要： The present invention relates, in general, to granulocytic ehrlichia (GE) proteins. In particular, the present invention relates to nucleic acid molecules coding for GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; purified GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; a method of detecting nucleic acids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with ehrlichiosis; therapeutic uses, specifically vaccines comprising S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides or nucleic acids; and methods of preventing or inhibiting ehrlichiosis in an animal.

    摘要翻译： 本发明一般涉及粒细胞性埃里希（GE）蛋白质。 特别地，本发明涉及编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质的核酸分子; 纯化的GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质和多肽; 重组核酸分子; 含有重组核酸分子的细胞; 具有GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质和多肽特异性结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白质的核酸的核酸探针; 检测样品中编码GE S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白或多肽的核酸的方法; 含有核酸探针或抗体的试剂盒; 使用本发明的核酸序列，蛋白质或抗体的生物测定来诊断，评估或预测患有埃里希氏菌病的哺乳动物; 特别是包含S2，S7，S22，S23，C6.1，C6.2，S11，E8，E46＃1和E46＃2蛋白或多肽或核酸的疫苗; 以及预防或抑制动物中的禽病毒的方法。

    APPARATUS HAVING THERMALLY ISOLATED VENTURI TUBE JOINTS
    4.
    发明申请
    APPARATUS HAVING THERMALLY ISOLATED VENTURI TUBE JOINTS 失效
    具有热隔离VENTURI管接头的装置

    公开(公告)号：US20060213178A1

    公开(公告)日：2006-09-28

    申请号：US10907248

    申请日：2005-03-25

    申请人： James Storey ,  Constantin Dinu

    发明人： James Storey ,  Constantin Dinu

    IPC分类号： F02C3/22

    CPC分类号： F02C3/22 ,  F23R3/286 ,  F23R3/40

    摘要： A gas fuel injector includes a first header plate, a second header plate, and a plurality of venturi tubes. The second header plate is spaced downstream from the first header plate. The plurality of venturi tubes is sealably secured to the first and second header plates. Each venturi tube of the plurality of venturi tubes is defined by a plurality of fixable components.

    摘要翻译： 气体燃料喷射器包括第一集管板，第二集管板和多个文氏管。 第二集管板与第一集管板的下游间隔开。 多个文丘里管可密封地固定到第一和第二集管板。 多个文丘里管的每个文氏管由多个可固定部件限定。

    Nucleic acids, proteins, and methods of use of granulocytic ehrlichia
    5.
    发明授权
    Nucleic acids, proteins, and methods of use of granulocytic ehrlichia 失效
    核酸，蛋白质和粒细胞性埃里希氏杆菌的使用方法

    公开(公告)号：US06306394B1

    公开(公告)日：2001-10-23

    申请号：US09066047

    申请日：1998-04-24

    申请人： Cheryl Murphy ,  James Storey ,  Gerald A. Beltz ,  Richard T. Coughlin

    发明人： Cheryl Murphy ,  James Storey ,  Gerald A. Beltz ,  Richard T. Coughlin

    IPC分类号： A61K3900

    CPC分类号： C07K14/29 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  Y02A50/403

    摘要： Nucleic acids encoding eleven different proteins of granulocytic erhlichia (GE), a tick-borne intracellular bacteria, have been isolated and sequenced completely. These DNAs were isolated as immunoreactive clones from a Lambda Zap II genomic library of GE DNA purified from infected HL60 cells. Three of the clones, E8, E80, and E46, contain open reading frames for four highly homologous proteins which appear to be part of a multigene family resembling the MSP-2 gene family of Anaplasma marginale. One clone, B3, contained a gene encoding the heat shock 70 protein. The other clones (W20, E74, and E82) contain open reading frames for proteins which have some homology to other bacterial proteins present in the nucleotide and protein databases. These and other GE antigens identified by immunoscreening of the genomic library are potentially useful as diagnostic reagents and vaccine candidates for GE.

    摘要翻译： 已经分离并测序了编码十一种不同蛋白质的颗粒细胞erhlichia（GE），一种蜱传播的细胞内细菌。 从被感染的HL60细胞纯化的GE DNA的λZapII基因组文库中分离这些DNA作为免疫反应性克隆。 三个克隆（E8，E80和E46）包含四个高度同源的蛋白质的开放阅读框架，这些蛋白质似乎是类似于Anaplasma limale的MSP-2基因家族的多基因家族的一部分。 一个克隆B3包含编码热休克70蛋白的基因。 其他克隆（W20，E74和E82）包含与核苷酸和蛋白质数据库中存在的其他细菌蛋白具有一定同源性的蛋白质的开放阅读框。 通过基因组文库的免疫筛选鉴定的这些和其他GE抗原潜在地用作GE的诊断试剂和疫苗候选物。

    MULTI-SIDED DIFFUSER FOR A VENTURI IN A FUEL INJECTOR FOR A GAS TURBINE
    8.
    发明申请
    MULTI-SIDED DIFFUSER FOR A VENTURI IN A FUEL INJECTOR FOR A GAS TURBINE 失效
    用于燃气涡轮机燃油喷射器的多功能搅拌器

    公开(公告)号：US20060000218A1

    公开(公告)日：2006-01-05

    申请号：US10879102

    申请日：2004-06-30

    申请人： Constantin Dinu ,  Iris Hu ,  James Storey

    发明人： Constantin Dinu ,  Iris Hu ,  James Storey

    IPC分类号： F23R3/28

    CPC分类号： F23R3/34 ,  F23R3/286 ,  F23R3/40

    摘要： A combustor for a gas turbine includes a main fuel injector for receiving compressor discharge air and mixing the air with fuel for flow to a downstream catalytic section. The main fuel injector includes an array of venturis each having an inlet, a throat and a diffuser. A main fuel supply plenum between forward and aft plates supplies fuel to secondary annular plenums having openings for supplying fuel into the inlets of the venturis upstream of the throats. Each diffuser transitions from a circular cross-section at the throat to multiple discrete angularly related side walls at the diffuser exit. Gaps between circumferentially and radially spaced diffusers at their exits are eliminated. With this arrangement, uniform flow distribution of the fuel/air, velocity and temperature is provided at the catalyst inlet.

    摘要翻译： 用于燃气轮机的燃烧器包括主燃料喷射器，用于接收压缩机排放空气并将空气与用于流动的燃料混合到下游催化部分。 主燃料喷射器包括每个具有入口，喉部和扩散器的孔的阵列。 前后板之间的主要燃料供应气室将燃料供给到具有用于将燃料供应到喉部上游的通风口的入口的开口的次级环形增压室。 每个扩散器从喉部的圆形横截面到扩散器出口处的多个离散的角度相关的侧壁。 在其出口处的周向和径向间隔的扩散器之间的间隙被消除。 通过这种布置，在催化剂入口处提供了燃料/空气，速度和温度的均匀流量分布。