发明授权
- 专利标题: Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
- 专利标题(中): 将伊伐布拉德及其加成盐与药学上可接受的酸合成的方法
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申请号: US11654719申请日: 2007-01-18
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公开(公告)号: US07867994B2公开(公告)日: 2011-01-11
- 发明人: Jean-Michel Lerestif , Jean-Pierre Lecouve , Jean-Claude Souvie , Daniel Brigot , Stephane Horvath , Marie-Noelle Auguste , Gerard Damien
- 申请人: Jean-Michel Lerestif , Jean-Pierre Lecouve , Jean-Claude Souvie , Daniel Brigot , Stephane Horvath , Marie-Noelle Auguste , Gerard Damien
- 申请人地址: FR Suresnes Cedex
- 专利权人: Les Laboratoires Servier
- 当前专利权人: Les Laboratoires Servier
- 当前专利权人地址: FR Suresnes Cedex
- 代理机构: Hueschen and Sage
- 优先权: FR0403830 20040413
- 主分类号: C07D223/16
- IPC分类号: C07D223/16 ; C07D405/06 ; A61K31/55 ; A61P9/00
摘要:
Process for the synthesis of ivabradine of formula (I): addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof. α crystalline form of ivabradine hydrochloride.Medicinal products containing α crystalline form of ivabradine hydrochloride, which are useful as bradycardics.
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