发明授权
- 专利标题： Compounds and compositions as protein kinase inhibitors
- 专利标题（中）： 化合物和组合物作为蛋白激酶抑制剂
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申请号： US11997113申请日： 2006-08-09
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公开(公告)号： US07868018B2公开(公告)日： 2011-01-11
- 发明人: Yongping Xie , Guobao Zhang , Xing Wang , Nathanael S. Gray , Yi Liu
- 申请人： Yongping Xie , Guobao Zhang , Xing Wang , Nathanael S. Gray , Yi Liu
- 申请人地址： BM Hamilton
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： BM Hamilton
- 代理机构： Genomics Institute of the Novartis Research Foundation
- 代理商 Scott W. Reid
- 国际申请： PCT/US2006/031134 WO 20060809
- 国际公布： WO2007/021795 WO 20070222
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/4375 ; A61P35/00 ; A61P37/00 ; A61P25/00 ; A61K31/519 ; C07D413/12 ; A61K31/5355 ; A61K31/4355 ; C07D491/147
摘要：
The invention provides compounds of Formula I: wherein R1-R6 are described in the Summary of the Invention; the pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, BMX, BTK, CHK2, b-RAF, c-RAF, CSK, c-SRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK2α2, Lck, Met, MKK4, MKK6, MST2, NEK2, p70S6K, PDGFRβ, PKA, PKBα, PKD2, Rsk1, SAPK2α, SAPK2β, SAPK3, SGK, Tie2 and TrkB kinases.
公开/授权文献
- US20080300246A1 Compounds and Compositions as Protein Kinase Inhibitors 公开/授权日：2008-12-04
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