发明授权
US07871786B2 GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof
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GEF-H1b：生物标志物，复合物，测定及其治疗用途
- 专利标题： GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof
- 专利标题（中）： GEF-H1b：生物标志物，复合物，测定及其治疗用途
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申请号： US12232134申请日： 2008-09-11
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公开(公告)号： US07871786B2公开(公告)日： 2011-01-18
- 发明人: Tod R. Smeal , Marinella G. Callow , Bahija Jallal , Sergey Zozulya , Mikhail L. Gishizky
- 申请人： Tod R. Smeal , Marinella G. Callow , Bahija Jallal , Sergey Zozulya , Mikhail L. Gishizky
- 申请人地址： US NY New York
- 专利权人： Sugen, Inc.
- 当前专利权人： Sugen, Inc.
- 当前专利权人地址： US NY New York
- 代理商 Austin W. Zhang; Jeffrey H. Tidwell
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K39/395 ; C07K16/00 ; C07K5/00
摘要：
The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
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