Invention Grant
- Patent Title: Residual solvent extraction method and microparticles produced thereby
- Patent Title (中): 残留溶剂萃取方法和由此产生的微粒
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Application No.: US12382637Application Date: 2009-03-20
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Publication No.: US07875310B2Publication Date: 2011-01-25
- Inventor: Michael E. Rickey , J. Michael Ramstack , Rajesh Kumar
- Applicant: Michael E. Rickey , J. Michael Ramstack , Rajesh Kumar
- Applicant Address: US MA Waltham
- Assignee: Alkermes, Inc.
- Current Assignee: Alkermes, Inc.
- Current Assignee Address: US MA Waltham
- Agency: Covington & Burling LLP
- Agent Andrea G. Reister, Esq.; Melody Wu, Esq.
- Main IPC: B01J13/12
- IPC: B01J13/12 ; A61K38/00
Abstract:
Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Public/Granted literature
- US20090194894A1 Residual solvent extraction method and microparticles produced thereby Public/Granted day:2009-08-06
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