发明授权
- 专利标题: Process for the preparation of dihydroxy esters and derivatives thereof
- 专利标题(中): 二羟基酯及其衍生物的制备方法
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申请号: US12768459申请日: 2010-04-27
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公开(公告)号: US07888083B2公开(公告)日: 2011-02-15
- 发明人: Andrew John Blacker , Christopher David Reeve , Robert Antony Holt
- 申请人: Andrew John Blacker , Christopher David Reeve , Robert Antony Holt
- 申请人地址: GB London
- 专利权人: AstraZeneca UK Limited
- 当前专利权人: AstraZeneca UK Limited
- 当前专利权人地址: GB London
- 代理机构: Morgan Lewis & Bockius LLP
- 优先权: GB0011120.3 20000509
- 主分类号: C12P7/62
- IPC分类号: C12P7/62 ; C07C69/66 ; C12N9/14
摘要:
A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
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