发明授权
- 专利标题: Interferon alpha and interferon kappa fusion protein
- 专利标题(中): 干扰素α和干扰素κ融合蛋白
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申请号: US12560391申请日: 2009-09-15
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公开(公告)号: US07888475B2公开(公告)日: 2011-02-15
- 发明人: Hal S. Padgett , Fakhrieh S. Vojdani , Andrew A. Vaewhongs
- 申请人: Hal S. Padgett , Fakhrieh S. Vojdani , Andrew A. Vaewhongs
- 代理商 Wayne P. Fitzmaurice
- 主分类号: C07K17/00
- IPC分类号: C07K17/00 ; C12N15/00 ; C07H21/04
摘要:
Herein is described a system to combat poxvirus infection wherein antagonists are developed that bind the soluble cytokine receptor but have no significant biological activity in the host, effectively blocking the virus-mediated suppressor of interferon function, thereby permitting the host's own cytokines to stimulate an antiviral response. Alternatively, interferon molecules can be developed that retain biological activity on their native receptors but fail to bind the viral cytokine binding protein, thereby circumventing this virus immune modulation mechanism.
公开/授权文献
- US20100121030A1 ANTAGONISM OR EVASION OF SOLUBLE CYTOKINE RECEPTORS 公开/授权日:2010-05-13