发明授权
- 专利标题: Glucokinase activators and methods of using same
- 专利标题(中): 葡糖激酶活化剂及其使用方法
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申请号: US11769799申请日: 2007-06-28
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公开(公告)号: US07888504B2公开(公告)日: 2011-02-15
- 发明人: Sean Chen , Peter T. W. Cheng , Rebecca A. Smirk
- 申请人: Sean Chen , Peter T. W. Cheng , Rebecca A. Smirk
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Maureen S. Gibbons; Burton Rodney
- 主分类号: C07D277/34
- IPC分类号: C07D277/34 ; C07D277/36 ; C07D277/38 ; C07D417/12 ; C07D403/12 ; A61K31/427 ; A61K31/506 ; A61P3/10
摘要:
Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is aryl or heteroaryl; R2 is halogen, cycloalkyl, heterocyclyl, aryl, or heteroaryl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or N4; R3, R4, and R5 are as defined herein; R8 is aryl or heteroaryl; R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
公开/授权文献
- US20080021052A1 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME 公开/授权日:2008-01-24
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