公开(公告)号：US08222285B2

公开(公告)日：2012-07-17

申请号：US12663807

申请日：2008-06-11

申请人： Sean Chen ,  Peter T. W. Cheng ,  Rebecca A. Smirk

发明人： Sean Chen ,  Peter T. W. Cheng ,  Rebecca A. Smirk

IPC分类号： A01N43/78 ,  A61K31/425

CPC分类号： C07D277/56 ,  C07D417/12 ,  C07D417/14 ,  C07F9/6539

摘要： Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R2 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or NR4; R3, R4, and R5 are as defined herein; R8 is aryl, heteroaryl, —PO(OR9)(OR10), —PO(OR9)R10 or —P(O)(R9)R10 (wherein R9 and R10 are as defined herein)/R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

摘要翻译： 提供作为葡糖激酶活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并且具有其中在环中表示一个或两个双键的结构; R 1是烷基，芳基，芳烷基，杂芳基或杂芳基烷基; R2是烷基，芳基，芳基烷基，杂芳基或杂芳基烷基; R5如本文所定义; Z是O，S，S（O），S（O）2或NR5a; X是S，O，N，NR 3或CR 3; Y是NCR4或NR4; R3，R4和R5如本文所定义; R8是芳基，杂芳基，-PO（OR9）（OR10），-PO（OR9）R10或-P（O）（R9）R10（其中R9和R10如本文所定义）/ R6和R7独立地是H，卤素 ，或烷基; m为0或1; 和n为0至3，或其药学上可接受的盐。 还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

公开(公告)号：US20100179121A1

公开(公告)日：2010-07-15

申请号：US12663807

申请日：2008-06-11

申请人： Sean Chen ,  Peter T.W. Cheng ,  Rebecca A. Smirk

发明人： Sean Chen ,  Peter T.W. Cheng ,  Rebecca A. Smirk

IPC分类号： A61K31/427 ,  C07D277/56 ,  C07D417/12 ,  A61K31/426 ,  A61K31/4439 ,  A61P7/12

CPC分类号： C07D277/56 ,  C07D417/12 ,  C07D417/14 ,  C07F9/6539

摘要： Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R2 is alkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or NR4; R3, R4, and R5 are as defined herein; R8 is aryl, heteroaryl, —PO(OR9)(OR10), —PO(OR9)R10 or —P(O)(R9)R10 (wherein R9 and R10 are as defined herein)/R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

摘要翻译： 提供作为葡糖激酶活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并且具有其中在环中表示一个或两个双键的结构; R 1是烷基，芳基，芳烷基，杂芳基或杂芳基烷基; R2是烷基，芳基，芳基烷基，杂芳基或杂芳基烷基; R5如本文所定义; Z是O，S，S（O），S（O）2或NR5a; X是S，O，N，NR 3或CR 3; Y是NCR4或NR4; R3，R4和R5如本文所定义; R8是芳基，杂芳基，-PO（OR9）（OR10），-PO（OR9）R10或-P（O）（R9）R10（其中R9和R10如本文所定义）/ R6和R7独立地是H，卤素 ，或烷基; m为0或1; 和n为0至3，或其药学上可接受的盐。 还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

公开(公告)号：US07888504B2

公开(公告)日：2011-02-15

申请号：US11769799

申请日：2007-06-28

申请人： Sean Chen ,  Peter T. W. Cheng ,  Rebecca A. Smirk

发明人： Sean Chen ,  Peter T. W. Cheng ,  Rebecca A. Smirk

IPC分类号： C07D277/34 ,  C07D277/36 ,  C07D277/38 ,  C07D417/12 ,  C07D403/12 ,  A61K31/427 ,  A61K31/506 ,  A61P3/10

CPC分类号： C07D417/14 ,  C07D277/46 ,  C07D417/12

摘要： Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is aryl or heteroaryl; R2 is halogen, cycloalkyl, heterocyclyl, aryl, or heteroaryl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or N4; R3, R4, and R5 are as defined herein; R8 is aryl or heteroaryl; R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

摘要翻译： 提供作为葡糖激酶活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并且具有其中在环中表示一个或两个双键的结构; R1是芳基或杂芳基; R2是卤素，环烷基，杂环基，芳基或杂芳基; R5如本文所定义; Z是O，S，S（O），S（O）2或NR5a; X是S，O，N，NR 3或CR 3; Y是NCR4或NR4; R3，R4和R5如本文所定义; R8是芳基或杂芳基; R6和R7独立地是H，卤素或烷基; m为0或1; 和n为0至3，或其药学上可接受的盐。 还提供了使用上述化合物治疗糖尿病和相关疾病的方法。