发明授权
US07893203B2 Protein involved in G protein-coupled receptor mediated signal transduction with ability to mediate signal transduction from a dopamine D1 receptor or an adenosine A2A receptor to an adenylate cyclase and utilization thereof
失效
涉及G蛋白偶联受体介导的信号转导的蛋白质，其能够介导从多巴胺D1受体或腺苷A2A受体到腺苷酸环化酶的信号转导及其利用
- 专利标题： Protein involved in G protein-coupled receptor mediated signal transduction with ability to mediate signal transduction from a dopamine D1 receptor or an adenosine A2A receptor to an adenylate cyclase and utilization thereof
- 专利标题（中）： 涉及G蛋白偶联受体介导的信号转导的蛋白质，其能够介导从多巴胺D1受体或腺苷A2A受体到腺苷酸环化酶的信号转导及其利用
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申请号： US12118247申请日： 2008-05-09
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公开(公告)号： US07893203B2公开(公告)日： 2011-02-22
- 发明人: Yasuhiko Takahashi , Yasuo Matsumoto , Kenji Oeda
- 申请人： Yasuhiko Takahashi , Yasuo Matsumoto , Kenji Oeda
- 申请人地址： JP Osaka
- 专利权人： Sumitomo Chemical Company, Ltd.
- 当前专利权人： Sumitomo Chemical Company, Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Panitch Schwarze Belisario & Nadel LLP
- 优先权： JP2002-206841 20020716; JP2002-367778 20021219; JP2003-095955 20030331
- 主分类号： C07K14/47
- IPC分类号： C07K14/47
摘要：
A novel protein (Gm1) includes an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein α subunits and a trimer forming domain conserved among G protein α subunits. The Gm1 protein is involved in signal transduction via a G protein-coupled receptor (GPCR) stimulation. The Gm1 protein is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. A method for screening for a substance capable of regulating a cellular signal transduction employs a polynucleotide encoding the Gm1 protein.
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