发明授权
- 专利标题： Heteroaryl derivatives as orexin receptor antagonists
- 专利标题（中）： 杂芳基衍生物作为食欲蛋白受体拮抗剂
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申请号： US12334559申请日： 2008-12-15
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公开(公告)号： US07897627B2公开(公告)日： 2011-03-01
- 发明人: Henner Knust , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 申请人： Henner Knust , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP07150294 20071221
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; A61K31/506 ; A61K31/501 ; A61K31/498 ; A61K31/4439 ; A61K31/427 ; A61K31/428 ; A61K31/4245 ; A61K31/423 ; C07D417/14 ; C07D417/12 ; C07D413/14 ; C07D413/12 ; C07D409/14 ; C07D405/14 ; C07D401/14 ; C07D403/12 ; C07D403/14
摘要：
The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and are useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder and sleep disorders associated with neurological diseases.
公开/授权文献
- US20090163485A1 HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS 公开/授权日：2009-06-25
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