发明授权
US07902168B2 Compositions and methods for inhibiting expression of Nav1.8 gene
有权
用于抑制Nav1.8基因表达的组合物和方法
- 专利标题： Compositions and methods for inhibiting expression of Nav1.8 gene
- 专利标题（中）： 用于抑制Nav1.8基因表达的组合物和方法
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申请号： US12487605申请日： 2009-06-18
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公开(公告)号： US07902168B2公开(公告)日： 2011-03-08
- 发明人: Dinah Wen-Yee Sah , Maria Frank-Kamenetsky , Anke Geick , Philipp Hadwiger , Ingo Roehl , Pamela Tan , Hans-Peter Vornlocher
- 申请人： Dinah Wen-Yee Sah , Maria Frank-Kamenetsky , Anke Geick , Philipp Hadwiger , Ingo Roehl , Pamela Tan , Hans-Peter Vornlocher
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Fenwick & West LLP
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; A61K31/70 ; C12N5/00
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.
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