发明授权
- 专利标题： NK1 antagonists
- 专利标题（中）： NK1拮抗剂
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申请号： US11358827申请日： 2006-02-21
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公开(公告)号： US07902366B2公开(公告)日： 2011-03-08
- 发明人: Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
- 申请人： Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
- 申请人地址： US FL Miami
- 专利权人： OPKO Health, Inc.
- 当前专利权人： OPKO Health, Inc.
- 当前专利权人地址： US FL Miami
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; C07D211/12
摘要：
A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
公开/授权文献
- US20060199815A1 NK1 antagonists 公开/授权日：2006-09-07
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