In a programmable logic device with a number of different types of serial interfaces, different power supply filtering schemes are applied to different interfaces. For interfaces operating at the lowest data rates—e.g., 1 Gbps—circuit-board level filtering including one or more decoupling capacitors may be provided. For interfaces operating at somewhat higher data rates—e.g., 3 Gbps—modest on-package filtering also may be provided, which may include power-island decoupling. For interfaces operating at still higher data rates—e.g., 6 Gbps—more substantial on-package filtering, including one or more on-package decoupling capacitors, also may be provided. For interfaces operating at the highest data rates—e.g., 10 Gbps—on-die filtering, which may include one or more on-die filtering or regulating networks, may be provided. The on-die regulators may be programmably bypassable allowing a user to trade off performance for power savings.