Invention Grant
US07906120B2 Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR)
有权
针对Nogo-66受体（NgR）的中和单克隆抗体
- Patent Title: Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR)
- Patent Title (中): 针对Nogo-66受体（NgR）的中和单克隆抗体
-
Application No.: US11943770Application Date: 2007-11-21
-
Publication No.: US07906120B2Publication Date: 2011-03-15
- Inventor: Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole E. Teusch
- Applicant: Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole E. Teusch
- Applicant Address: US IL Abbott Park
- Assignee: Abbott Laboratories
- Current Assignee: Abbott Laboratories
- Current Assignee Address: US IL Abbott Park
- Agent Sreenivasarao Vepachedu
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12P21/08
Abstract:
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
Public/Granted literature
- US20080279859A1 NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF Public/Granted day:2008-11-13
Information query
