发明授权
US07906120B2 Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR)
有权
针对Nogo-66受体（NgR）的中和单克隆抗体
- 专利标题： Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR)
- 专利标题（中）： 针对Nogo-66受体（NgR）的中和单克隆抗体
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申请号： US11943770申请日： 2007-11-21
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公开(公告)号： US07906120B2公开(公告)日： 2011-03-15
- 发明人: Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole E. Teusch
- 申请人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole E. Teusch
- 申请人地址： US IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： US IL Abbott Park
- 代理商 Sreenivasarao Vepachedu
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12P21/08
摘要：
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
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