发明授权
US07910320B2 Methods compositions and compound assays for inhibiting amyloid-beta protein production
有权
用于抑制淀粉样蛋白β蛋白生产的方法组合物和化合物测定法
- 专利标题： Methods compositions and compound assays for inhibiting amyloid-beta protein production
- 专利标题（中）： 用于抑制淀粉样蛋白β蛋白生产的方法组合物和化合物测定法
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申请号： US12190888申请日： 2008-08-13
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公开(公告)号： US07910320B2公开(公告)日： 2011-03-22
- 发明人: Pascal Gerard Merchiers , Marcel Hoffman , Koenraad Frederik Florentina Spittaels
- 申请人： Pascal Gerard Merchiers , Marcel Hoffman , Koenraad Frederik Florentina Spittaels
- 申请人地址： BE Mechelen
- 专利权人： Galapagos N.V.
- 当前专利权人： Galapagos N.V.
- 当前专利权人地址： BE Mechelen
- 代理商 Martin Savitzky
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/542 ; G01N33/566 ; G01N33/567 ; C12P21/00 ; C12P21/06 ; C12Q1/66
摘要：
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
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