发明授权
- 专利标题: Non-nucleotide reverse transcriptase inhibitors
- 专利标题(中): 非核苷酸逆转录酶抑制剂
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申请号: US10584933申请日: 2004-12-30
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公开(公告)号: US07915295B2公开(公告)日: 2011-03-29
- 发明人: Christian Sund , Nathalie Roue , Stefan Lindstrom , Dmitry Antonov , Christer Sahlberg , Katarina Jansson
- 申请人: Christian Sund , Nathalie Roue , Stefan Lindstrom , Dmitry Antonov , Christer Sahlberg , Katarina Jansson
- 申请人地址: SE Huddinge
- 专利权人: Medivir AB
- 当前专利权人: Medivir AB
- 当前专利权人地址: SE Huddinge
- 代理机构: Birch, Stewart, Kolasch and Birch, LLP
- 优先权: SE0400021 20040108; SE0400585 20040309
- 国际申请: PCT/SE2004/002034 WO 20041230
- 国际公布: WO2005/066131 WO 20050721
- 主分类号: A61K31/453
- IPC分类号: A61K31/453 ; C07D405/12
摘要:
Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from —S(═O)pRa, where Ra is —C1-C4 alkyl, —ORx, —NRxRx, —NHNRxRx, —NHNHC(═O)ORx, —NRxOH; —C(═O)—Rb, where Rb is —CT-C4-alkyl, ORx, —NRxRx, —NHNRxRx, —NHC1-C3-alkyl-C(═O)Orx —NRxRc, where Rc is H, C1-C4 alkyl, —NRxRx; —C(=0)Rd, —CN, S(═O)pRx, where Rd is Rd is C1-C4-alkyl, —ORx, —NRxRx C1-C3-alkyl-O—C1-C3-alkylC(═O)ORx, —C1-C3-alkyl-COORx; —C1-C3alkyl-OH or C1-C4 alkyl ethers or esters thereof (O—C1-C3alkyl)q-O—Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, —S(═O)—, or —CH2—, where r is 0, 1 or 2; R3-R7 are substituents as defined in the specification; X is —(CR8R8′)n-D-(CR8R8′)m-; D is a bond, —NR9—, -0-, —S—, —S(=0)- or —S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.
公开/授权文献
- US20080070951A1 Non-Nucleotide Reverse Transcriptase Inhibitors 公开/授权日:2008-03-20
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