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    Non-nucleoside reverse transcriptase inhibitors
    2.
    发明申请
    Non-nucleoside reverse transcriptase inhibitors 失效
    非核苷逆转录酶抑制剂

    公开(公告)号：US20060167055A1

    公开(公告)日：2006-07-27

    申请号：US10526598

    申请日：2003-09-05

    申请人： Dmitry Antonov ,  Christian Sund ,  Stefan Lindstrom ,  Christer Sahlberg

    发明人： Dmitry Antonov ,  Christian Sund ,  Stefan Lindstrom ,  Christer Sahlberg

    IPC分类号： A61K31/4433 ,  A61K31/4436 ,  C07D409/02

    CPC分类号： C07D213/73 ,  C07D213/65 ,  C07D307/93 ,  C07D311/94 ,  C07D333/78 ,  C07D335/06 ,  C07D405/12 ,  Y02P20/582

    摘要： A compound of the formula (Y): where; R1 is O, S; R2 is a nitrogen-containing heterocycle; R3 is H, C1-C3 alkyl; X is —(C8R8)n-D-(C8C8′)m—; D is a bond, —NR9—, —O—, —S—, —S(═O)— or —S(═O)2; n and m are independently 0, 1 or 2, R8 and R8′ are independently H, C1-C3 alkyl, haloC1-C3alkyl, hydroxy, or R8 and R8′ together with their adjacent C atom is —C(═O)—; R9 is independently H, C1-C3 alkyl; E is CH2—, —CHOH—, —C(═O)—, —NR9—, —O—, —S—, —S(═O)2—; n and m are independently 0, 1 or 2; p and q are independently 0, 1 or 2, where p+q≦2; R10 is an optionally substituted carbocycle or heterocycle; R11 is independently H, C1-C3 alkyl, halo substituted C1-C3alkyl, hydroxy; have utility as HIV antivirals.

    摘要翻译： 式（Y）的化合物：其中; R 1是O，S; R 2是含氮杂环; R 3是H，C 1 -C 3烷基; X是 - （C 8 R 8） - - - - （C 8 C 8） / SUB>'） D是键，-NR 9 - ， - O - ， - S - ， - S（-O） - 或-S（-O）2。 n和m独立地为0,1或2，R 8和R 8独立地为H，C 1 -C 3 烷基，卤代C 1 -C 3烷基，羟基或R 8和R 8' 与它们相邻的C原子一起是-C（-O） - ; R 9独立地是H，C 1 -C 3烷基; E是CH 2 - ， - CHOH - ， - C（-O） - ， - NR 9 - ， - O - ， - S - ， - S（-O ）＆lt; 2＆gt; - ; n和m独立地为0,1或2; p和q独立地为0,1或2，其中p + q <= 2; R 10是任选取代的碳环或杂环; R 11独立地是H，C 1 -C 3烷基，卤素取代的C 1 -C 3烷基， 3烷基，羟基; 具有艾滋病毒抗病毒药物的作用。

    Chuck having an integrated cone or machine spindle
    3.
    发明授权
    Chuck having an integrated cone or machine spindle 失效
    卡盘具有集成的锥形或机床

    公开(公告)号：US5462293A

    公开(公告)日：1995-10-31

    申请号：US216013

    申请日：1994-03-21

    申请人： Anders Samelius ,  Bjorn Ohlson ,  Stefan Lindstrom

    发明人： Anders Samelius ,  Bjorn Ohlson ,  Stefan Lindstrom

    IPC分类号： B23B31/02 ,  B23B31/117 ,  B23B31/30

    CPC分类号： B23B31/305 ,  Y10T279/1216 ,  Y10T279/24 ,  Y10T408/76 ,  Y10T409/30952

    摘要： A rotating holder for tools or work pieces includes a chuck in the form of a hydraulic clamp bushing. The clamp bushing comprises a thin inner sleeve or wall, a solid outer sleeve and a plastic or hydraulic pressure medium which is entrapped between the sleeves. The thin inner sleeve is arranged to both center and firmly clamp a rotating tool or work piece when the hydraulic pressure medium is being pressurized. The clamp bushing is integrated with a mounting cone or with a machine spindle by a welding or soldering joint. The clamp bushing is formed with a bore at the periphery thereof for providing an opening to some type of means for pressurizing the hydraulic pressure medium. A protection ring is formed around the periphery of the clamp bushing and is rotatable to at least two positions, in one position of which the protection ring covers the bore for the pressurization means and in another position of which a passageway is opened to the pressurization means. The clamp bushing also can have one or more fine-balancing bores which are drilled into the material thereof and which are likewise covered by the protection ring.

    摘要翻译： 用于工具或工件的旋转保持器包括液压夹具衬套形式的卡盘。 夹紧衬套包括薄的内套管或壁，固体外套筒和夹在套管之间的塑料或液压介质。 当液压介质被加压时，薄的内套筒布置成中心并牢固地夹紧旋转的工具或工件。 夹紧衬套通过焊接或焊接接头与安装锥体或机床主体集成。 夹紧衬套在其周边形成有孔，用于为某些类型的用于对液压介质加压的装置提供开口。 保护环围绕夹紧套管的周边形成，并且可旋转至少两个位置，其一个位置中保护环覆盖用于加压装置的孔，并且其另一个位置通向开口的加压装置 。 夹紧衬套还可以具有一个或多个精细平衡孔，钻孔材料同样被保护环覆盖。

    Heat Exchange Medium
    4.
    发明申请
    Heat Exchange Medium 审中-公开
    换热介质

    公开(公告)号：US20130269635A1

    公开(公告)日：2013-10-17

    申请号：US13699933

    申请日：2010-12-16

    申请人： Mats Arrhenborg ,  Stefan Lindstrom

    发明人： Mats Arrhenborg ,  Stefan Lindstrom

    IPC分类号： C09K5/10 ,  F01P3/00

    CPC分类号： C09K5/10 ,  C10L1/08 ,  F01P3/00

    摘要： The present invention relates to the replacement of water and glycol mixtures by a synthetically made diesel as cooling medium, for instance engine coolant in vehicles. The synthetic diesel is environmental-friendly, usable in a wide temperature range, functions as corrosion protection in radiator systems, and transports heat better than water does.

    摘要翻译： 本发明涉及通过合成制造的柴油作为冷却介质（例如车辆中的发动机冷却剂）来代替水和乙二醇混合物。 合成柴油环保，可在宽温度范围内使用，作为散热器系统的防腐保护，比水更好地运输热量。

    Non-nucleotide reverse transcriptase inhibitors
    5.
    发明授权
    Non-nucleotide reverse transcriptase inhibitors 有权
    非核苷酸逆转录酶抑制剂

    公开(公告)号：US07915295B2

    公开(公告)日：2011-03-29

    申请号：US10584933

    申请日：2004-12-30

    申请人： Christian Sund ,  Nathalie Roue ,  Stefan Lindstrom ,  Dmitry Antonov ,  Christer Sahlberg ,  Katarina Jansson

    发明人： Christian Sund ,  Nathalie Roue ,  Stefan Lindstrom ,  Dmitry Antonov ,  Christer Sahlberg ,  Katarina Jansson

    IPC分类号： A61K31/453 ,  C07D405/12

    CPC分类号： C07D409/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14

    摘要： Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from —S(═O)pRa, where Ra is —C1-C4 alkyl, —ORx, —NRxRx, —NHNRxRx, —NHNHC(═O)ORx, —NRxOH; —C(═O)—Rb, where Rb is —CT-C4-alkyl, ORx, —NRxRx, —NHNRxRx, —NHC1-C3-alkyl-C(═O)Orx —NRxRc, where Rc is H, C1-C4 alkyl, —NRxRx; —C(=0)Rd, —CN, S(═O)pRx, where Rd is Rd is C1-C4-alkyl, —ORx, —NRxRx C1-C3-alkyl-O—C1-C3-alkylC(═O)ORx, —C1-C3-alkyl-COORx; —C1-C3alkyl-OH or C1-C4 alkyl ethers or esters thereof (O—C1-C3alkyl)q-O—Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, —S(═O)—, or —CH2—, where r is 0, 1 or 2; R3-R7 are substituents as defined in the specification; X is —(CR8R8′)n-D-(CR8R8′)m-; D is a bond, —NR9—, -0-, —S—, —S(=0)- or —S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.

    摘要翻译： 式Z的化合物：其中; A是CH或N; R 1是含有选自-S（= O）p R a的A的环中的碳原子的取代基，其中R a是-C 1 -C 4烷基，-OR x，-NR x R x，-NHNR x R x，-NHNHC（= O）OR x， NR x OH; -C（= O）-R b，其中R b是-CT-C 4 - 烷基，OR x，-NR x R x，-NHNR x R x，-NHC 1 -C 3烷基-C（= O）Or x -NR x R c，其中R c是H， C4烷基，-NRxRx; -C（= O）R d，-CN，S（= O）p R x，其中Rd是Rd是C 1 -C 4烷基，-OR x，-NR x R x C 1 -C 3烷基-O-C 1 -C 3 - 烷基C（= O ）ORx，-C1-C3-烷基-COORx; -C 1 -C 3烷基-OH或C 1 -C 4烷基醚或其酯（O-C 1 -C 3烷基）q-O-R 1具有1-3个杂原子的5或6元芳环p为1或2; R x独立地选自H，C 1 -C 4烷基或乙酰基; 或一对Rx可与相邻的N原子一起形成环; L是-O - ， - S（= O） - 或-CH 2 - ，其中r是0,1或2; R3-R7是说明书中定义的取代基; X是 - （CR8R8'）n-D-（CR8R8'）m-; D是键，-NR 9 - ， - O - ， - S - ， - S（= O） - 或-S（= O） 其药学上可接受的盐和前药具有作为HIV抗病毒剂的效用。

    Hydromechanical chuck
    7.
    发明授权
    Hydromechanical chuck 失效
    液压机械卡盘

    公开(公告)号：US06224067B1

    公开(公告)日：2001-05-01

    申请号：US09355451

    申请日：1999-08-25

    申请人： Stefan Lindstrom

    发明人： Stefan Lindstrom

    IPC分类号： B23B3120

    CPC分类号： B23B31/204 ,  B23B31/305 ,  Y10T279/1266 ,  Y10T279/17307 ,  Y10T279/17316 ,  Y10T279/17521

    摘要： A hydromechanical chuck intended to be mounted, with one end thereof, in a machine, such as a drilling machine, milling machine, lathe machine etc. and, with the opposite end thereof to releasably hold a shaft tool like a drill, a milling tool, a rotary saw blade, or a rotary grinding roll. The hydromechanical chuck is formed as a cone coupling chuck comprising a inner sleeve which can change is radial dimensions and has a central bore for receiving the shaft of a shaft tool. The inner sleeve is adapted for being radially compressed against the tool shaft. The hydromechanical chuck has a solid outer sleeve which is axially displaceable on the inner sleeve. The inner sleeve and outer sleeve are formed with a matching cone surface, which, upon a displacement of the outer sleeve on the inner sleeve, provides a radial compression of the inner sleeve. The chuck is formed with a hydraulic clamp pressure chamber comprising a hydraulic pressure medium which, upon pressurization, displaces the outer sleeve on the inner sleeve, thereby connecting the tool. A pressure release chamber releases the joint between the chuck and the tool.

    摘要翻译： 一种液压机械卡盘，其一端安装在机器中，例如钻床，铣床，车床机等，并且其相对端可释放地保持诸如钻头的轴工具，铣刀 ，旋转锯片或旋转研磨辊。 液压机械卡盘形成为锥形联接卡盘，该卡盘包括可以改变为径向尺寸的内部套筒，并具有用于接收轴工具的轴的中心孔。 内套筒适于径向压靠在工具轴上。 液压机械卡盘具有可在内套筒上轴向移动的实心外套筒。 内套筒和外套筒形成有匹配的锥形表面，当内套筒上的外套筒移位时，其提供内套筒的径向压缩。 卡盘形成有液压夹紧压力室，其包括液压介质，该液压介质在加压时将内套筒上的外套筒移位，从而连接工具。 压力释放室释放卡盘和工具之间的接头。

    Non-Nucleotide Reverse Transcriptase Inhibitors
    10.
    发明申请
    Non-Nucleotide Reverse Transcriptase Inhibitors 有权
    非核苷酸逆转录酶抑制剂

    公开(公告)号：US20080070951A1

    公开(公告)日：2008-03-20

    申请号：US10584933

    申请日：2004-12-30

    申请人： Christian Sund ,  Nathalie Roue ,  Stefan Lindstrom ,  Dmitry Antonov ,  Christer Sahlberg ,  Katarina Jansson

    发明人： Christian Sund ,  Nathalie Roue ,  Stefan Lindstrom ,  Dmitry Antonov ,  Christer Sahlberg ,  Katarina Jansson

    IPC分类号： A61K31/44 ,  A61P31/18 ,  C07D211/00

    CPC分类号： C07D409/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14

    摘要： Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from —S(═O)pRa, where Ra is —C1-C4 alkyl, —ORx, —NRxRx, —NHNRxRx, —NHNHC(═O)ORx, —NRxOH; —C(═O)—Rb, where Rb is —CT-C4-alkyl, ORx, —NRxRx, —NHNRxRx, —NHC1-C3-alkyl-C(═O)Orx —NRxRc, where Rc is H, C1-C4 alkyl, —NRxRx; —C(=0)Rd, —CN, S(═O)pRx, where Rd is Rd is C1-C4-alkyl, —ORx, —NRxRx C1-C3-alkyl-O—C1-C3-alkylC(═O)ORx, —C1-C3-alkyl-COORx; —C1-C3alkyl-OH or C1-C4 alkyl ethers or esters thereof (O—C1-C3alkyl)q-O—Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is —O —, —S(═O)—, or —CH2—, where r is 0, 1 or 2; R3-R7 are substituents as defined in the specification; X is —(CR8R8′)n-D-(CR8R8′)m-; D is a bond, —NR9—, —O—, —S—, —S(=0)- or —S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.

    摘要翻译： 式Z的化合物：其中; A是CH或N; R 1是含有选自-S（-O）n R a的A的环中的碳原子的取代基，其中R a是-C 1 - -O - ， - NR x R x，-NHNR x R x，-NHNHC（-O）OR x，-NR x OH; -C（-O）-R b，其中R b是-C 1 -C 4烷基，OR x，-NR x R x，-NHNR x R x，-NHC 1 -C 3 - 烷基 - C（-O）OR x -NR x R c，其中R c是H，C 1 -C 4烷基，-NR x R x; -C（= O）R d，-CN，S（-O）p R x，其中Rd是Rd是C 1 -C 4 - 烷基，-OR x，-NR x R x C 1 -C 3 - / - 烷基-O-C 1 -C 3 - 烷基C（O）OR x，-C 1 -C 3 - 烷基-COOR x; -C 1 -C 3烷基-OH或C 1 -C 4烷基醚或其酯（OC 烷基）qO-Rx，具有1-3个杂原子的5或6元芳环p为1或2; R x独立地选自H，C 1 -C 4烷基或乙酰基; 或一对Rx可与相邻的N原子一起形成环; L是-O - ， - S（-O） - 或-CH 2 - ，其中r是0,1或2; R 3 -R 7是说明书中定义的取代基; X是 - （CR 8 R 8 8）n-D-（CR 8 R 8）m - ; D是键，-NR 9 - ， - O - ， - S - ， - S（= O） - 或-S（= O）2 - 其药学上可接受的盐和前药具有作为HIV抗病毒剂的效用。