发明授权
US07919089B2 Pharmaceutical composition comprising a bispecific antibody for EpCAM
有权
包含用于EpCAM的双特异性抗体的药物组合物
- 专利标题: Pharmaceutical composition comprising a bispecific antibody for EpCAM
- 专利标题(中): 包含用于EpCAM的双特异性抗体的药物组合物
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申请号: US10554851申请日: 2004-05-26
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公开(公告)号: US07919089B2公开(公告)日: 2011-04-05
- 发明人: Peter Kufer , Meera Berry , Sonja Offner , Klaus Brischwein , Andreas Wolf , Tobias Raum , Birgit Kohleisen , Ulla Lenkkeri-Schutz , Patrick Baeuerle
- 申请人: Peter Kufer , Meera Berry , Sonja Offner , Klaus Brischwein , Andreas Wolf , Tobias Raum , Birgit Kohleisen , Ulla Lenkkeri-Schutz , Patrick Baeuerle
- 申请人地址: DE Munich
- 专利权人: Micromet AG
- 当前专利权人: Micromet AG
- 当前专利权人地址: DE Munich
- 代理机构: Foley & Lardner LLP
- 优先权: EP03012133 20030531; EP03012134 20030531
- 国际申请: PCT/EP2004/005687 WO 20040526
- 国际公布: WO2004/106383 WO 20041209
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/00 ; C07K16/24
摘要:
The present invention provides a pharmaceutical composition comprising a bispecific single chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise or consist of at least two domains, whereby one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the amino acid sequence NXID antigen and a second domain binds to human CD3 antigen. The invention further provides a process for the production of the pharmaceutical composition of the invention, a method for the prevention, treatment or amelioration of a tumorous disease and the use of the disclosed bispecific single chain antibody construct and corresponding means in the prevention, treatment or amelioration of a tumorous disease.