发明授权
US07928085B2 P-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazole[4,5-d]pyrimidine-2-one and methods for preparation
有权
5-氨基-3-(2'-O-乙酰基-3'-脱氧-β-呋喃核糖基)-3H-噻唑并[4,5-d]嘧啶-2-酮的对甲苯磺酸盐和 制备方法
- 专利标题: P-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazole[4,5-d]pyrimidine-2-one and methods for preparation
- 专利标题(中): 5-氨基-3-(2'-O-乙酰基-3'-脱氧-β-呋喃核糖基)-3H-噻唑并[4,5-d]嘧啶-2-酮的对甲苯磺酸盐和 制备方法
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申请号: US11873202申请日: 2007-10-16
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公开(公告)号: US07928085B2公开(公告)日: 2011-04-19
- 发明人: David Kucera , Gregory J. Haley , Erik J. Rueden , Tingmin Wang , Fritz Blatter , Martin Viertelhaus
- 申请人: David Kucera , Gregory J. Haley , Erik J. Rueden , Tingmin Wang , Fritz Blatter , Martin Viertelhaus
- 申请人地址: US CA San Diego
- 专利权人: Anadys Pharmaceuticals, Inc.
- 当前专利权人: Anadys Pharmaceuticals, Inc.
- 当前专利权人地址: US CA San Diego
- 代理机构: Connolly Bove Lodge & Hutz LLP
- 主分类号: C07H19/00
- IPC分类号: C07H19/00 ; A61K31/70 ; A01N43/04
摘要:
The present disclosure relates to p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and to its use in treating conditions such as viral infections, tumors, and cancer. Also disclosed is a method of preparing the p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and methods for producing furanose compounds which are useful intermediates in the preparation of pharmaceutical compounds such as p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.
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