发明授权
- 专利标题： Nucleic acid detection assays employing blocker oligonucleotides
- 专利标题（中）： 使用封闭寡核苷酸的核酸检测试验
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申请号： US12360819申请日： 2009-01-27
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公开(公告)号： US07932039B2公开(公告)日： 2011-04-26
- 发明人: Poonam Agarwal , Robert W. Kwiatkowski, Jr.
- 申请人： Poonam Agarwal , Robert W. Kwiatkowski, Jr.
- 申请人地址： US WI Madison
- 专利权人： Third Wave Technologies, Inc.
- 当前专利权人： Third Wave Technologies, Inc.
- 当前专利权人地址： US WI Madison
- 代理机构： Casimir Jones, S.C.
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/02 ; C07H21/04
摘要：
The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the formation of invasive cleavage structures with the interfering sequences but do not substantially inhibit the formation of invasive cleavage structures with the target sequences.
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