Invention Grant
- Patent Title: Conformationally constrained Smac mimetics and the uses thereof
- Patent Title (中): 构象约束的Smac模拟物及其用途
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Application No.: US10586271Application Date: 2005-01-18
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Publication No.: US07932382B2Publication Date: 2011-04-26
- Inventor: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu
- Applicant: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones, S.C.
- International Application: PCT/US2005/001406 WO 20050118
- International Announcement: WO2005/069894 WO 20050804
- Main IPC: C07D487/00
- IPC: C07D487/00
Abstract:
The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Public/Granted literature
- US20080269140A1 Conformationally Constrained Smac Mimetics and the Uses Thereof Public/Granted day:2008-10-30
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