发明授权
- 专利标题: Aryloxy-substituted benzimidazole derivatives
- 专利标题(中): 芳氧基取代的苯并咪唑衍生物
-
申请号: US11666555申请日: 2005-11-01
-
公开(公告)号: US07932394B2公开(公告)日: 2011-04-26
- 发明人: Noriaki Hashimoto , Keiji Takahashi , Chisato Nakama , Yoshio Ogino , Fumiko Sakai , Teruyuki Nishimura , Jun-ichi Eiki
- 申请人: Noriaki Hashimoto , Keiji Takahashi , Chisato Nakama , Yoshio Ogino , Fumiko Sakai , Teruyuki Nishimura , Jun-ichi Eiki
- 申请人地址: JP Chiyoda-Ku
- 专利权人: MSD K.K.
- 当前专利权人: MSD K.K.
- 当前专利权人地址: JP Chiyoda-Ku
- 代理商 Richard C. Billups; Heidi M. Struse; John C. Todaro
- 优先权: JP2004-319339 20041102; JP2005-178628 20050617
- 国际申请: PCT/JP2005/020483 WO 20051101
- 国际公布: WO2006/049304 WO 20060511
- 主分类号: C07D401/00
- IPC分类号: C07D401/00 ; A61K31/445
摘要:
A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided.The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.
公开/授权文献
- US20080125429A1 Aryloxy-Substituted Benzimidazole Derivatives 公开/授权日:2008-05-29