Invention Grant
US07932402B2 Process for preparing an intermediate to opioid receptor antagonists
有权
制备中间体至MU阿片受体拮抗剂的方法
- Patent Title: Process for preparing an intermediate to opioid receptor antagonists
- Patent Title (中): 制备中间体至MU阿片受体拮抗剂的方法
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Application No.: US12218383Application Date: 2008-07-15
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Publication No.: US07932402B2Publication Date: 2011-04-26
- Inventor: Pierre-Jean Colson , Ying Yu , Daniel D. Long , Ioanna Stergiades
- Applicant: Pierre-Jean Colson , Ying Yu , Daniel D. Long , Ioanna Stergiades
- Applicant Address: US CA San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA San Francisco
- Agent Jeffrey A. Hagenah; Roberta P. Saxon
- Main IPC: C07D209/52
- IPC: C07D209/52
Abstract:
The invention provides an efficient method for preparing 3-endo-(8-azabicyclo[3.2.1]oct-3-yl)benzamide by hydrogenation, under controlled conditions, of an amino-protected 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)benzamide intermediate in which the amino-protecting group is removable by catalytic hydrogenation.
Public/Granted literature
- US20090023934A1 Process for preparing an intermediate to opioid receptor antagonists Public/Granted day:2009-01-22
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