Invention Grant
US07935500B2 Identifying calcineurin activators for treatment of schizophrenia
失效
鉴定用于治疗精神分裂症的钙调神经磷酸酶激活剂
- Patent Title: Identifying calcineurin activators for treatment of schizophrenia
- Patent Title (中): 鉴定用于治疗精神分裂症的钙调神经磷酸酶激活剂
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Application No.: US10400348Application Date: 2003-03-26
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Publication No.: US07935500B2Publication Date: 2011-05-03
- Inventor: David J. Gerber , Maria Karayiorgou , Tsuyoshi Miyakawa , Susumu Tonegawa
- Applicant: David J. Gerber , Maria Karayiorgou , Tsuyoshi Miyakawa , Susumu Tonegawa
- Applicant Address: US MA Cambridge US NY New York
- Assignee: Massachusetts Institute of Technology,Rockefeller University
- Current Assignee: Massachusetts Institute of Technology,Rockefeller University
- Current Assignee Address: US MA Cambridge US NY New York
- Agency: Choate Hall & Stewart LLP
- Agent Fangli Chen
- Main IPC: C12Q1/34
- IPC: C12Q1/34 ; C12Q1/68 ; C12Q1/02 ; G01N33/53 ; G01N33/15
Abstract:
The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens.
Public/Granted literature
- US20040014095A1 Targets, methods, and reagents for diagnosis and treatment of schizophrenia Public/Granted day:2004-01-22
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