发明授权
US07935695B2 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
失效
可用作烟碱乙酰胆碱受体配体的1,4-二氮杂双环[3.2.2]壬基杂芳基衍生物
![1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands](/docs/US/2011-05-03/US07935695B2/abs.jpg.600x600.jpg)
- 专利标题： 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
- 专利标题（中）： 可用作烟碱乙酰胆碱受体配体的1,4-二氮杂双环[3.2.2]壬基杂芳基衍生物
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申请号： US12733168申请日： 2008-08-14
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公开(公告)号： US07935695B2公开(公告)日： 2011-05-03
- 发明人: Dan Peters , Daniel B. Timmermann , Elsebet Ostergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen
- 申请人： Dan Peters , Daniel B. Timmermann , Elsebet Ostergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen
- 申请人地址： DK Ballerup
- 专利权人： Neurosearch A/S
- 当前专利权人： Neurosearch A/S
- 当前专利权人地址： DK Ballerup
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： DK200701178 20070817
- 国际申请： PCT/EP2008/060654 WO 20080814
- 国际公布： WO2009/024517 WO 20090226
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D243/00 ; C07D487/22 ; C07D491/00 ; C07D498/00
![1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands](/abs-image/US/2011/05/03/US07935695B2/abs.jpg.150x150.jpg)
摘要：
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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