发明授权
- 专利标题: Formulations which stabilize and inhibit precipitation of immunogenic compositions
- 专利标题(中): 稳定和抑制免疫原性组合物沉淀的制剂
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申请号: US11737674申请日: 2007-04-19
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公开(公告)号: US07935787B2公开(公告)日: 2011-05-03
- 发明人: Lakshmi Khandke , Ronald Malone , Xudong Yang , Hanyoung Han , Jee Loon Look , Zhaowei Jin , Robert C. Seid, Jr. , Ying Chen
- 申请人: Lakshmi Khandke , Ronald Malone , Xudong Yang , Hanyoung Han , Jee Loon Look , Zhaowei Jin , Robert C. Seid, Jr. , Ying Chen
- 申请人地址: US NJ Madison
- 专利权人: Wyeth LLC
- 当前专利权人: Wyeth LLC
- 当前专利权人地址: US NJ Madison
- 主分类号: A61K31/715
- IPC分类号: A61K31/715 ; C07K14/00
摘要:
The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.
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