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    Vaccines for Haemophilus influenzae
    2.
    发明授权
    Vaccines for Haemophilus influenzae 失效
    流感嗜血杆菌疫苗

    公开(公告)号：US5098997A

    公开(公告)日：1992-03-24

    申请号：US239572

    申请日：1988-09-01

    申请人： Algis Anilionis ,  Robert C. Seid, Jr. ,  Robert A. Deich ,  Gary W. Zlotnick ,  Bruce A. Green

    发明人： Algis Anilionis ,  Robert C. Seid, Jr. ,  Robert A. Deich ,  Gary W. Zlotnick ,  Bruce A. Green

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/285 ,  C07K16/12 ,  C12N15/62 ,  C12N15/70 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569

    CPC分类号： G01N33/56911 ,  C07K14/285 ,  C07K16/1242 ,  C12N15/625 ,  C12N15/70 ,  C12Q1/689 ,  C12Q1/701 ,  G01N33/56983 ,  A61K38/00 ,  A61K39/00 ,  C07K2317/34 ,  C07K2319/02 ,  C07K2319/035 ,  C07K2319/40 ,  Y10S435/851 ,  Y10S530/806 ,  Y10S530/825

    摘要： Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host cells. The peptides, proteins, fusion proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides, proteins and fusion proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides, proteins and fusion proteins in hybridization assays is also described.

    摘要翻译： 描述了与包含流感嗜血杆菌的外膜蛋白的表位相关的肽和蛋白质。 肽和蛋白质可以通过包括来自流感嗜血杆菌培养物的新颖和改进的纯化方法以及重组DNA和化学合成技术的方法制备。 此外，还描述了含有编码PBOMP-1和PBOMP-2相关肽，蛋白质和融合蛋白的核苷酸序列的重组载体。 重组载体包括质粒DNA和病毒DNA，例如人类病毒，动物病毒，昆虫病毒和噬菌体，其在适当的宿主细胞中引导PBOMP-1和PBOMP-2相关肽，蛋白质和融合蛋白的表达。 “活”和“灭活”的肽，蛋白质，融合蛋白和病毒用作疫苗制剂中的免疫原，以防止流感嗜血杆菌感染。 肽，蛋白质和融合蛋白也用作免疫测定中的试剂，并且用于制备用于被动免疫的免疫球蛋白。 还描述了在杂交测定中使用编码PBOMP相关肽，蛋白质和融合蛋白的核苷酸序列。

    Recombinant vectors for Haemophilus influenzae peptides and proteins
    4.
    发明授权
    Recombinant vectors for Haemophilus influenzae peptides and proteins 失效
    流感嗜血杆菌肽和蛋白质的重组载体

    公开(公告)号：US5196338A

    公开(公告)日：1993-03-23

    申请号：US480396

    申请日：1990-02-15

    申请人： Algis Anilionis ,  Robert C. Seid, Jr. ,  Robert A. Deich ,  Gary W. Zlotnick ,  Bruce A. Green

    发明人： Algis Anilionis ,  Robert C. Seid, Jr. ,  Robert A. Deich ,  Gary W. Zlotnick ,  Bruce A. Green

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/285 ,  C07K16/12 ,  C12N15/62 ,  C12N15/70 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569

    CPC分类号： C07K14/285 ,  C07K16/1242 ,  C12N15/625 ,  C12N15/70 ,  C12Q1/689 ,  C12Q1/701 ,  G01N33/56911 ,  G01N33/56983 ,  A61K38/00 ,  A61K39/00 ,  C07K2317/34 ,  C07K2319/02 ,  C07K2319/035 ,  C07K2319/40

    摘要： Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host cells. The peptides, proteins, fusion proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides, proteins and fusion proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides, proteins and fusion proteins in hybridization assays is also described.

    摘要翻译： 描述了与包含流感嗜血杆菌的外膜蛋白的表位相关的肽和蛋白质。 肽和蛋白质可以通过包括来自流感嗜血杆菌培养物的新颖和改进的纯化方法以及重组DNA和化学合成技术的方法制备。 此外，还描述了含有编码PBOMP-1和PBOMP-2相关肽，蛋白质和融合蛋白的核苷酸序列的重组载体。 重组载体包括质粒DNA和病毒DNA，例如人类病毒，动物病毒，昆虫病毒和噬菌体，其在适当的宿主细胞中引导PBOMP-1和PBOMP-2相关肽，蛋白质和融合蛋白的表达。 “活”和“灭活”的肽，蛋白质，融合蛋白和病毒用作疫苗制剂中的免疫原，以防止流感嗜血杆菌感染。 肽，蛋白质和融合蛋白也用作免疫测定中的试剂，并且用于制备用于被动免疫的免疫球蛋白。 还描述了在杂交测定中使用编码PBOMP相关肽，蛋白质和融合蛋白的核苷酸序列。