Device, system, and method of wireless network selection and handover. A multi-transceiver wireless device includes: at least first and second co-located wireless transceivers; one or more firmware modules to handle network selection of at least one of the first and second wireless transceivers based on one or more commands received from one or more drivers when the multi-transceiver wireless device is in full-power mode; and a manageability engine to handle network selection of at least one of the first and second wireless transceivers when the multi-transceiver wireless device is in reduced-power mode.