发明授权
US07939250B2 Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives
有权
维生素K环氧化物再循环多肽VKORC1，香豆素及其衍生物的治疗靶点
- 专利标题： Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives
- 专利标题（中）： 维生素K环氧化物再循环多肽VKORC1，香豆素及其衍生物的治疗靶点
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申请号： US10965694申请日： 2004-10-14
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公开(公告)号： US07939250B2公开(公告)日： 2011-05-10
- 发明人: Johannes Oldenburg , Clemens R. Müller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
- 申请人： Johannes Oldenburg , Clemens R. Müller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
- 申请人地址： US IL Deerfield CH Wallisellen
- 专利权人： Baxter International Inc.,Baxter Healthcare S.A.
- 当前专利权人： Baxter International Inc.,Baxter Healthcare S.A.
- 当前专利权人地址： US IL Deerfield CH Wallisellen
- 代理机构： McAndrews Held & Malloy Ltd.
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N9/02 ; C12N15/70 ; C12P21/06 ; C07H21/04
摘要：
The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
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