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1.发明申请Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives 有权维生素K环氧化物再循环多肽VKORC1，香豆素及其衍生物的治疗靶点公开(公告)号：US20050271644A1
公开(公告)日：2005-12-08
申请号：US10965694
申请日：2004-10-14
CPC分类号： C12N9/0006 , A01K67/0276 , A01K2267/01 , C07K16/40 , C12N15/1137 , C12N15/115 , C12N15/62 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Q1/26 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Y101/04001
摘要： The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
摘要翻译： 本发明涉及作为香豆素及其衍生物的靶标的新型多肽维生素K环氧化物再循环多肽（VKORC1）。 本发明还提供了鉴定香豆素衍生物的方法，并且还要求含有与VKORC1相关缺陷如华法林抗性相关的序列异常的VKORC1多肽和VKORC1核酸，其中VKORC1多肽和VKORC1核酸可用于诊断这些缺陷。 此外，本发明涉及鉴定可用于啮齿动物害虫控制的香豆素衍生物的方法。
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2.发明申请Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives 审中-公开维生素K环氧化物回收多肽VKORC1，香豆素及其衍生物的治疗靶标公开(公告)号：US20110154520A1
公开(公告)日：2011-06-23
申请号：US12943260
申请日：2010-11-10
申请人： Johannes Oldenburg , Clemens R. Mueller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
发明人： Johannes Oldenburg , Clemens R. Mueller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
IPC分类号： A01K67/027 , C12N9/04 , C07H21/04 , C12N9/96 , C12N15/63 , C12N5/10 , C07H21/02 , C07K16/40 , C12Q1/68 , C12Q1/26 , G01N33/573 , C07D311/20
CPC分类号： C12N9/0006 , A01K67/0276 , A01K2267/01 , C07K16/40 , C12N15/1137 , C12N15/115 , C12N15/62 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Q1/26 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Y101/04001
摘要： The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
摘要翻译： 本发明涉及作为香豆素及其衍生物的靶标的新型多肽维生素K环氧化物再循环多肽（VKORC1）。 本发明还提供了鉴定香豆素衍生物的方法，并且还要求含有与VKORC1相关缺陷如华法林抗性相关的序列异常的VKORC1多肽和VKORC1核酸，其中VKORC1多肽和VKORC1核酸可用于诊断这些缺陷。 此外，本发明涉及鉴定可用于啮齿动物害虫控制的香豆素衍生物的方法。
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3.发明授权Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives 有权维生素K环氧化物再循环多肽VKORC1，香豆素及其衍生物的治疗靶点公开(公告)号：US07939250B2
公开(公告)日：2011-05-10
申请号：US10965694
申请日：2004-10-14
申请人： Johannes Oldenburg , Clemens R. Müller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
发明人： Johannes Oldenburg , Clemens R. Müller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
CPC分类号： C12N9/0006 , A01K67/0276 , A01K2267/01 , C07K16/40 , C12N15/1137 , C12N15/115 , C12N15/62 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Q1/26 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Y101/04001
摘要： The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
摘要翻译： 本发明涉及作为香豆素及其衍生物的靶标的新型多肽维生素K环氧化物再循环多肽（VKORC1）。 本发明还提供了鉴定香豆素衍生物的方法，并且还要求含有与VKORC1相关缺陷如华法林抗性相关的序列异常的VKORC1多肽和VKORC1核酸，其中VKORC1多肽和VKORC1核酸可用于诊断这些缺陷。 此外，本发明涉及鉴定可用于啮齿动物害虫控制的香豆素衍生物的方法。
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4.发明申请Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives 审中-公开维生素K环氧化物回收多肽VKORC1，香豆素及其衍生物的治疗靶标公开(公告)号：US20090094708A1
公开(公告)日：2009-04-09
申请号：US12205619
申请日：2008-09-05
申请人： Johannes Oldenburg , Clemens R. Muller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
发明人： Johannes Oldenburg , Clemens R. Muller-Reible , Andreas Fregin , Simone Rost , Tim-Matthias Strom
IPC分类号： A01K67/00 , C07K14/435 , C07H21/04 , C07H21/02 , C12P21/06 , C12Q1/68 , C12Q1/02 , C07K16/00 , C12N15/63 , C12N5/00
CPC分类号： C12N9/0006 , A01K67/0276 , A01K2267/01 , C07K16/40 , C12N15/1137 , C12N15/115 , C12N15/62 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Q1/26 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Y101/04001
摘要： The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
摘要翻译： 本发明涉及作为香豆素及其衍生物的靶标的新型多肽维生素K环氧化物再循环多肽（VKORC1）。 本发明还提供了鉴定香豆素衍生物的方法，并且还要求含有与VKORC1相关缺陷如华法林抗性相关的序列异常的VKORC1多肽和VKORC1核酸，其中VKORC1多肽和VKORC1核酸可用于诊断这些缺陷。 此外，本发明涉及鉴定可用于啮齿动物害虫控制的香豆素衍生物的方法。
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