发明授权
- 专利标题： Process for the preparation of levetiracetam
- 专利标题（中）： 左乙拉西坦的制备方法
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申请号： US12561616申请日： 2009-09-17
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公开(公告)号： US07939676B2公开(公告)日： 2011-05-10
- 发明人: Corrado Colli , Massimiliano Forcato , Livius Cotarca
- 申请人： Corrado Colli , Massimiliano Forcato , Livius Cotarca
- 申请人地址： IT Bresso (MI)
- 专利权人： Zach System S.p.A.
- 当前专利权人： Zach System S.p.A.
- 当前专利权人地址： IT Bresso (MI)
- 代理机构： Lucas & Mercanti, LLP
- 主分类号： C07D207/06
- IPC分类号： C07D207/06 ; C07D207/08
摘要：
A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (−)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.
公开/授权文献
- US20110065932A1 Process for the preparation of Levetiracetam 公开/授权日：2011-03-17