发明授权
- 专利标题： Liquid buffered GDF-5 formulations
- 专利标题（中）： 液体缓冲GDF-5制剂
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申请号： US12420260申请日： 2009-04-08
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公开(公告)号： US07947649B2公开(公告)日： 2011-05-24
- 发明人: Dongling Su , Julius Lopez
- 申请人： Dongling Su , Julius Lopez
- 申请人地址： US MA Raynham
- 专利权人： Advanced Technologies and Regenerative Medicine, LLC
- 当前专利权人： Advanced Technologies and Regenerative Medicine, LLC
- 当前专利权人地址： US MA Raynham
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/16 ; A61K38/17 ; A61K38/18 ; C07K14/00 ; C07K14/435 ; C07K14/46 ; C07K14/47 ; C07K14/475
摘要：
Improved formulations and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an acetate buffered solution of GDF-5 and other excipients wherein the solution has a pH of from about 4.2 to about 5.3, thereby providing for a biologically isotonic solution having improved stability of the GDF-5 protein during storage, handling, and use.
公开/授权文献
- US20090259023A1 LIQUID BUFFERED GDF-5 FORMULATIONS 公开/授权日：2009-10-15
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