发明授权
- 专利标题： Pyrrolidine derivatives as histamine H3 receptor antagonists
- 专利标题（中）： 吡咯烷衍生物作为组胺H3受体拮抗剂
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申请号： US11908501申请日： 2006-03-13
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公开(公告)号： US07951826B2公开(公告)日： 2011-05-31
- 发明人: Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , Cynthia Darshini Jesudason , Richard Todd Pickard , Freddie Craig Stevens , Takako Takakuwa
- 申请人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , Cynthia Darshini Jesudason , Richard Todd Pickard , Freddie Craig Stevens , Takako Takakuwa
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 Dan L. Wood
- 国际申请： PCT/US2006/008943 WO 20060313
- 国际公布： WO2006/101808 WO 20060928
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61K31/4025 ; C07D401/14 ; C07D403/06
摘要：
The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
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