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公开(公告)号：US07951826B2
公开(公告)日：2011-05-31
申请号：US11908501
申请日：2006-03-13
申请人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , Cynthia Darshini Jesudason , Richard Todd Pickard , Freddie Craig Stevens , Takako Takakuwa
发明人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , Cynthia Darshini Jesudason , Richard Todd Pickard , Freddie Craig Stevens , Takako Takakuwa
IPC分类号： A61K31/4439 , A61K31/4025 , C07D401/14 , C07D403/06
CPC分类号： C07D207/09 , C07D401/14
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法和中间体。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。
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公开(公告)号：US20080207732A1
公开(公告)日：2008-08-28
申请号：US11908501
申请日：2006-03-13
申请人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , Cynthia Darshini Jesudason , Richard Todd Pickard , Freddie Craig Stevens , Takako Takakuwa
发明人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , Cynthia Darshini Jesudason , Richard Todd Pickard , Freddie Craig Stevens , Takako Takakuwa
IPC分类号： A61K31/4025 , C07D403/06
CPC分类号： C07D207/09 , C07D401/14
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法和中间体。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。
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公开(公告)号：US08008296B2
公开(公告)日：2011-08-30
申请号：US11917941
申请日：2006-06-28
申请人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
发明人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
IPC分类号： A61K31/535 , A61K31/497 , A61K31/445 , C07D413/00 , C07D409/00 , C07D207/00
CPC分类号： C07D207/09 , C07D401/12 , C07D403/12
摘要： The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I).
摘要翻译： 本发明公开了具有组胺-3H受体拮抗剂或反向激动剂活性的式I化合物或其药学上可接受的盐以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。 （式I）。
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公开(公告)号：US20100048580A1
公开(公告)日：2010-02-25
申请号：US12610954
申请日：2009-11-02
申请人： Lisa Selsam Beavers , Don Richard Finley , Terry Patrick Finn , Robert Alan Gadski , Philip Arthur Hipskind , Wiliam Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
发明人： Lisa Selsam Beavers , Don Richard Finley , Terry Patrick Finn , Robert Alan Gadski , Philip Arthur Hipskind , Wiliam Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
IPC分类号： A61K31/501 , C07D403/06 , C07D413/14 , C07D403/14 , C07D401/14 , A61K31/506 , A61K31/4439 , A61K31/4245 , A61K31/4025
CPC分类号： C07D207/09 , C07D401/10 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法
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公开(公告)号：US20100160319A1
公开(公告)日：2010-06-24
申请号：US11917941
申请日：2006-06-28
申请人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
发明人： Lisa Selsam Beavers , Don Richard Finley , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
IPC分类号： A61K31/5377 , C07D207/04 , C07D401/14 , C07D403/14 , C07D413/14 , A61K31/4025 , A61K31/454 , A61K31/497 , A61K31/4439 , A61P25/00
CPC分类号： C07D207/09 , C07D401/12 , C07D403/12
摘要： The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. (Formula I)
摘要翻译： 本发明公开了具有组胺-3H受体拮抗剂或反向激动剂活性的式I化合物或其药学上可接受的盐以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。 （式I）
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公开(公告)号：US08008301B2
公开(公告)日：2011-08-30
申请号：US12610954
申请日：2009-11-02
申请人： Lisa Selsam Beavers , Don Richard Finley , Terry Patrick Finn , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
发明人： Lisa Selsam Beavers , Don Richard Finley , Terry Patrick Finn , Robert Alan Gadski , Philip Arthur Hipskind , William Joseph Hornback , Cynthia Darshini Jesudason , Richard Todd Pickard , Takako Takakuwa , Grant Mathews Vaught
IPC分类号： A61K31/501 , A61K31/4439 , A61K31/4245 , A61K31/4025 , C07D403/06 , C07D413/14 , C07D401/14
CPC分类号： C07D207/09 , C07D401/10 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine—H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor—related diseases
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法
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公开(公告)号：US08178528B2
公开(公告)日：2012-05-15
申请号：US11909727
申请日：2006-03-28
申请人： Philip Arthur Hipskind , Takako Takakuwa , Cynthia Darshini Jesudason , Robert Alan Gadski , William Joseph Hornback , Richard Todd Pickard , Lisa Selsam Beavers
发明人： Philip Arthur Hipskind , Takako Takakuwa , Cynthia Darshini Jesudason , Robert Alan Gadski , William Joseph Hornback , Richard Todd Pickard , Lisa Selsam Beavers
IPC分类号： A61K31/535 , A61K31/497 , A61K31/445 , C07D413/00 , C07D409/00 , C07D207/00
CPC分类号： C07D207/09 , C07D401/06
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine—H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法和中间体。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用这些组合物治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。
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公开(公告)号：US07902191B2
公开(公告)日：2011-03-08
申请号：US10598262
申请日：2005-02-22
申请人： Lisa Selsam Beavers , Robert Alan Gadski , Philip Arthur Hipskind , Cynthia Darshini Jesudason , Karen Lynn Lobb , Richard Todd Pickard , Craig William Lindsley
发明人： Lisa Selsam Beavers , Robert Alan Gadski , Philip Arthur Hipskind , Cynthia Darshini Jesudason , Karen Lynn Lobb , Richard Todd Pickard , Craig William Lindsley
IPC分类号： A01N43/40 , A61K31/445 , A61K31/497 , A61K31/535 , C07D207/00 , C07D211/06 , C07D295/00 , C07D403/00 , C07D413/00
CPC分类号： C07D295/125 , C07D207/09 , C07D295/02 , C07D295/096 , C07D295/155 , C07D295/192 , C07D487/04
摘要： The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases.
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂活性的式I化合物或其药学上可接受的盐以及其制备方法。 在另一个实施方案中，本发明公开了包含式I化合物的药物组合物以及使用它们治疗肥胖症和其他组胺H3受体相关疾病的方法。
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公开(公告)号：US20100160406A1
公开(公告)日：2010-06-24
申请号：US11909727
申请日：2006-03-28
申请人： Philip Arthur Hipskind , Takako Takakuwa , Cynthia Darshini Jesudason , Robert Alan Gadski , William Joseph Hornback , Richard Todd Pickard , Lisa Selsman Beavers
发明人： Philip Arthur Hipskind , Takako Takakuwa , Cynthia Darshini Jesudason , Robert Alan Gadski , William Joseph Hornback , Richard Todd Pickard , Lisa Selsman Beavers
IPC分类号： A61K31/4025 , C07D403/06 , A61P31/04
CPC分类号： C07D207/09 , C07D401/06
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
摘要翻译： 本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法和中间体。 在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用这些组合物治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。
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10.发明授权Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses 失效非咪唑芳基烷基胺化合物作为组胺H3受体拮抗剂，制备和治疗用途公开(公告)号：US07314937B2
公开(公告)日：2008-01-01
申请号：US10472675
申请日：2002-03-21
申请人： Lisa Selsam Beavers , Robert Alan Gadski , Philip Arthur Hipskind , Craig William Lindsley , Karen Lynn Lobb , James Arthur Nixon , Richard Todd Pickard , John Mehnert Schaus , Takako Takakuwa , Brian Morgan Watson
发明人： Lisa Selsam Beavers , Robert Alan Gadski , Philip Arthur Hipskind , Craig William Lindsley , Karen Lynn Lobb , James Arthur Nixon , Richard Todd Pickard , John Mehnert Schaus , Takako Takakuwa , Brian Morgan Watson
IPC分类号： C07D217/22 , A61K31/47
CPC分类号： C07D207/27 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/58 , C07D213/38 , C07D217/04 , C07D217/06 , C07D217/08 , C07D217/24 , C07D231/04 , C07D231/14 , C07D233/36 , C07D233/54 , C07D235/14 , C07D241/44 , C07D243/08 , C07D295/088 , C07D295/13 , C07D295/15 , C07D307/14 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D417/06 , C07D471/04
摘要： The present invention discloses novel substituted aryl alkylamine compounds of Formula (I) or pharmaceutically acceptable salts thereof which have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such cyclic amines as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases
摘要翻译： 本发明公开了具有选择性组胺H3受体拮抗剂活性的式（I）的新型取代芳基烷基胺化合物或其药学上可接受的盐以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含这种环胺的药物组合物以及使用它们治疗肥胖症和其他组胺H3受体相关疾病的方法
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