发明授权
US07956196B2 1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication
有权
1,3-二氢 - 苯并咪唑-2-亚基胺作为呼吸道合胞病毒复制的抑制剂
- 专利标题: 1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication
- 专利标题(中): 1,3-二氢 - 苯并咪唑-2-亚基胺作为呼吸道合胞病毒复制的抑制剂
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申请号: US11908538申请日: 2006-03-17
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公开(公告)号: US07956196B2公开(公告)日: 2011-06-07
- 发明人: Jean-François Bonfanti , Jérôme Michel Claude Fortin , Ismet Dorange
- 申请人: Jean-François Bonfanti , Jérôme Michel Claude Fortin , Ismet Dorange
- 申请人地址: IE
- 专利权人: Tibotec Pharmaceuticals Ltd.
- 当前专利权人: Tibotec Pharmaceuticals Ltd.
- 当前专利权人地址: IE
- 优先权: EP05102127 20050317
- 国际申请: PCT/EP2006/060852 WO 20060317
- 国际公布: WO2006/097534 WO 20060921
- 主分类号: A61K31/4184
- IPC分类号: A61K31/4184 ; A61K31/5377 ; C07D235/30 ; C07D401/12 ; C07D401/14 ; C07D413/14
摘要:
Novel 1,3-dihydro-benzimidazol-2-ylidene amine derivatives of formula the addition salts and stereochemically isomeric forms wherein each Alk is C1-6alkanediyl; Q is hydrogen; C1-6alkyl substituted with one or two Ar2 radicals; C1-6alkyl substituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl; —CO—Ar2; or Q is a radical of formula wherein t is 1, 2 or 3; R4 is amino, mono-or di(C1-6alkyl)amino; R1 is Ar2, —CO—Ar2 or a monocyclic or bicyclic heterocycle which may optionally be substituted; R2 is as R1 and additionally can be hydrogen; where Q is other than hydrogen, R3 is hydrogen; and where Q is other than hydrogen, R3 is a radical: wherein R6 is hydrogen, C1-6alkyl, substituted C1-6alkyl; R7, R8, R9 are halo, cyano, C1-6alkyl, substituted C1-6alkyl, C2-6alkenyl, cyanoC2-6alkenyl, C2-6alkynyl, cyanoC2 6alkynyl, Ar1, R10a—0—, R10a—S—, —N(R5aR5b), R10a—O—C(═O)—, N(R5aR5b)—C(═O)—, R10a—C(═O)—NR5b—, R10b—C(═O)—O—; and R8 and/or R9 may also be hydrogen; which are RSV inhibitors. Compositions containing these compounds and processes for preparing these compounds and compositions.
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