发明授权
US07964359B2 Compositions and methods for the enhancement of soluble amyloid beta oligomer (ADDL) uptake and clearance
有权
用于增强可溶性淀粉样蛋白β寡聚物（ADDL）吸收和清除的组合物和方法
- 专利标题： Compositions and methods for the enhancement of soluble amyloid beta oligomer (ADDL) uptake and clearance
- 专利标题（中）： 用于增强可溶性淀粉样蛋白β寡聚物（ADDL）吸收和清除的组合物和方法
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申请号： US11747324申请日： 2007-05-11
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公开(公告)号： US07964359B2公开(公告)日： 2011-06-21
- 发明人: Wei-Qin Zhao , Grant A. Krafft , William L. Klein
- 申请人： Wei-Qin Zhao , Grant A. Krafft , William L. Klein
- 申请人地址： US CA South San Francisco US IL Evanston
- 专利权人： Acumen Pharmaceuticals, Inc.,Northwestern University
- 当前专利权人： Acumen Pharmaceuticals, Inc.,Northwestern University
- 当前专利权人地址： US CA South San Francisco US IL Evanston
- 代理机构： Licata & Tyrrell P.C.
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K38/28
摘要：
The present invention relates to methods for enhancing the cellular uptake and clearance of soluble oligomeric Aβ peptide assemblies from the environment surrounding both neuronal and non-neuronal cells. Oligomeric Aβ peptide assembly uptake and clearance is achieved via an agent that enhances insulin receptor signaling. Such ADDL uptake enhancers represent effective anti-ADDL therapeutics for use in the therapeutic treatment and/or prophylactic treatment of diseases including Alzheimer's disease, Down's syndrome, and the like, in which compromised nerve cell function is linked to the formation and/or the activity of soluble oligomeric Aβ peptide assemblies, also known as ADDLs, and ADDL-related assemblies.
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