发明授权
- 专利标题: Tricyclic benzopyrane compound
- 专利标题(中): 三环苯并吡喃化合物
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申请号: US12591353申请日: 2009-11-17
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公开(公告)号: US07964623B2公开(公告)日: 2011-06-21
- 发明人: Kazuhiko Ohrai , Yukohiro Shigeta , Osamu Uesugi , Takumi Okada , Tomoyuki Matsuda
- 申请人: Kazuhiko Ohrai , Yukohiro Shigeta , Osamu Uesugi , Takumi Okada , Tomoyuki Matsuda
- 申请人地址: JP Tokyo
- 专利权人: Nissan Chemical Industries Ltd.
- 当前专利权人: Nissan Chemical Industries Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Oliff & Berridge, PLC
- 优先权: JP2004-084605 20040323
- 主分类号: A61K31/429
- IPC分类号: A61K31/429 ; C07D513/06
摘要:
This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.
公开/授权文献
- US20100069374A1 Tricyclic benzopyrane compound 公开/授权日:2010-03-18